| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | MM1; PLEXB2; Nbla00445; dJ402G11.3 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human PLXNB2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇与PLXNB2抗体相关的模拟参考文献示例(注：实际文献需通过学术数据库查询，以下内容为示例性概括)：
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1. **文献名称**: *PLXNB2 Antibody Reveals Its Role in Neuronal Axon Guidance*
**作者**: Smith A, et al.
**摘要**: 该研究开发了一种高特异性抗PLXNB2单克隆抗体，证实其在斑马鱼模型中参与轴突导向调控，并揭示PLXNB2与Semaphorin配体的相互作用机制。
2. **文献名称**: *Anti-PLXNB2 as a Potential Biomarker in Colorectal Cancer*
**作者**: Chen L, et al.
**摘要**: 通过免疫组化分析，发现PLXNB2在结直肠癌组织中高表达，其抗体可作为预后标志物，并提示PLXNB2通过激活MAPK通路促进肿瘤侵袭。
3. **文献名称**: *Development of a PLXNB2 Neutralizing Antibody for Therapeutic Targeting*
**作者**: Wang Y, et al.
**摘要**: 研究团队利用噬菌体展示技术筛选出能阻断PLXNB2与受体结合的抗体，体外实验显示其可抑制肿瘤细胞迁移，为癌症治疗提供新策略。
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建议通过PubMed或Web of Science搜索关键词“PLXNB2 antibody”获取真实文献。
Plexin B2 (PLXNB2) is a transmembrane receptor belonging to the plexin family, which plays critical roles in cell-cell signaling by interacting with semaphorins. It is involved in regulating diverse biological processes, including axon guidance, cell migration, immune response, and tissue development. Structurally, PLXNB2 contains a large extracellular domain for ligand binding, a transmembrane region, and an intracellular domain that mediates downstream signaling through interactions with Rho GTPases and other cytoskeletal regulators. Dysregulation of PLXNB2 has been implicated in pathological conditions such as cancer progression, neurodevelopmental disorders, and vascular abnormalities. For instance, elevated PLXNB2 expression correlates with tumor invasiveness in glioblastoma and breast cancer, likely by promoting metastatic signaling pathways.
PLXNB2 antibodies are essential tools for studying its expression, localization, and functional mechanisms. These antibodies are typically developed against specific epitopes within the extracellular or intracellular domains of PLXNB2 and are validated for applications like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). Commercially available PLXNB2 antibodies often undergo rigorous specificity testing, including knockout validation, to ensure accurate detection. Researchers utilize these antibodies to explore PLXNB2's role in disease models, its interaction with ligands like Sema4C, and its crosstalk with oncogenic pathways such as ErbB2-mediated signaling. Additionally, PLXNB2-targeting antibodies hold therapeutic potential, particularly in blocking pro-invasive signaling in cancers or modulating immune responses in inflammatory diseases.
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