| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | SSP1; SUSP1 |
| WB Predicted band size | 126 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human SENP6 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇与SENP6抗体相关的文献示例(基于截至2021年的研究，部分为模拟概括)：
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1. **标题**：SENP6 regulates DNA damage response through deSUMOylation of KDM5A
**作者**：Li R, et al.
**摘要**：研究利用SENP6抗体进行免疫共沉淀(Co-IP)实验，发现SENP6通过去除KDM5A蛋白的SUMO修饰，调控组蛋白H3K4甲基化水平，从而影响DNA损伤修复效率。
2. **标题**：SENP6-mediated deSUMOylation controls dynamic assembly of the mitotic checkpoint complex
**作者**：Yin Y, et al.
**摘要**：通过SENP6抗体的免疫荧光定位，揭示SENP6在有丝分裂中通过去SUMO化修饰调控MAD2蛋白复合体的动态组装，维持染色体分离的准确性。
3. **标题**：SENP6 antagonizes HIF-1α signaling via deSUMOylation of HDAC1 in hypoxia
**作者**：Wang X, et al.
**摘要**：研究使用SENP6抗体进行Western blot分析，证明低氧条件下SENP6通过调节HDAC1的SUMO化状态，抑制HIF-1α的转录活性，影响肿瘤细胞代谢适应。
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注：以上为模拟示例，实际文献需通过PubMed或Google Scholar以"SENP6 antibody"或"SENP6 SUMO protease"为关键词检索获取。近年来研究多聚焦于SENP6在基因组稳定性、肿瘤发生及蛋白质复合体动态调控中的作用。
SENP6 (Sentrin-specific protease 6) is a member of the SUMO (Small Ubiquitin-like Modifier)-specific protease family, which plays a critical role in the dynamic regulation of SUMOylation, a post-translational modification involved in diverse cellular processes. Unlike other SENP proteases that primarily cleave SUMO precursors or deconjugate SUMO from substrates, SENP6 specializes in editing poly-SUMO chains by trimming or disassembling them, thereby modulating SUMO chain topology and substrate interactions. This activity is essential for maintaining genomic stability, DNA repair, and cell cycle progression. SENP6 preferentially interacts with SUMO-2/3 isoforms and exhibits a unique substrate preference for poly-SUMOylated proteins, such as those in the SUMO-targeted ubiquitin ligase (STUbL) pathway.
Antibodies targeting SENP6 are crucial tools for studying its expression, localization, and molecular functions. These antibodies are typically validated for applications like Western blotting, immunofluorescence, and immunoprecipitation to detect SENP6 in cell lysates or tissue samples. Given SENP6's involvement in critical pathways, its dysregulation has been linked to diseases, including cancer and neurodegenerative disorders. Researchers use SENP6 antibodies to explore its role in SUMOylation dynamics, particularly in contexts like stress responses or mitotic regulation. Specificity and cross-reactivity validation are essential, as SENP6 shares structural homology with other SENP family members. High-quality SENP6 antibodies enable precise investigation of its regulatory mechanisms, aiding the development of therapeutic strategies targeting SUMO-mediated pathways.
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