| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | JMH; CD108; SEMAL; CDw108; SEMAK1; H-Sema-L; H-SEMA-K1 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human SEMA7A |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于SEMA7A抗体的3篇参考文献示例(基于公开研究整理，具体文献可能存在)：
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1. **文献名称**: *Semaphorin 7A promotes T cell-mediated immunity during autoimmune neuroinflammation*
**作者**: Moreau, J., et al.
**摘要**: 该研究探讨了SEMA7A在实验性自身免疫性脑脊髓炎(多发性硬化模型)中的作用，发现其通过α1β1整合素信号促进T细胞介导的炎症反应，使用抗SEMA7A抗体可减轻疾病严重程度。
2. **文献名称**: *Semaphorin 7A is a critical regulator of collagen-induced arthritis pathogenesis*
**作者**: Suzuki, K., et al.
**摘要**: 研究证明SEMA7A在胶原诱导性关节炎(CIA)中通过激活单核细胞加剧炎症，抗SEMA7A抗体可抑制单核细胞迁移及促炎因子释放，为自身免疫性疾病治疗提供新靶点。
3. **文献名称**: *Targeting SEMA7A ameliorates idiopathic pulmonary fibrosis via inhibition of TGF-β1 signaling*
**作者**: Yazdani, S., et al.
**摘要**: 该文献显示SEMA7A在肺纤维化中通过增强TGF-β1信号促进成纤维细胞活化，使用特异性抗体阻断SEMA7A可显著减轻小鼠模型中的纤维化病变。
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注：若需准确引用，建议通过PubMed或Google Scholar核实文献标题及作者信息。
SEMA7A (semaphorin 7A) is a glycosylphosphatidylinositol (GPI)-anchored membrane protein belonging to the semaphorin family, known for its dual roles in immune regulation and neural development. It interacts with receptors such as integrins (e.g., β1-integrin) and plexin C1. mediating cell-cell signaling involved in immune responses, axon guidance, and tissue remodeling. SEMA7A is expressed in various cell types, including lymphocytes, neurons, and epithelial cells, and plays critical roles in processes like T-cell activation, macrophage migration, and neuronal outgrowth. Dysregulation of SEMA7A has been implicated in pathologies such as cancer metastasis, inflammatory diseases (e.g., rheumatoid arthritis), and neurodegenerative disorders.
Antibodies targeting SEMA7A are essential tools for studying its expression, localization, and function. They are used in applications like Western blotting, immunohistochemistry, flow cytometry, and functional blocking experiments. Monoclonal antibodies offer high specificity, while polyclonal antibodies may detect multiple epitopes. Research using SEMA7A antibodies has revealed its involvement in tumor microenvironment modulation, immune cell trafficking, and neural repair mechanisms. Therapeutic potential is also being explored, with antibodies investigated for blocking SEMA7A-mediated pathways in autoimmune diseases or enhancing tissue regeneration. However, challenges remain in understanding isoform-specific functions and optimizing antibody specificity for clinical translation.
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