| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | Pr; pr1/Pr2; PRP-1/PRP-2 |
| WB Predicted band size | 17 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human PRH2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇关于PRH2抗体的文献摘要概览：
1. **《PRH2在胃癌组织中的表达及临床意义》**
- 作者：李明等
- 摘要：通过免疫组化技术分析PRH2蛋白在胃癌组织中的表达，发现PRH2抗体特异性识别癌变组织中高表达的PRH2.提示其可能作为胃癌诊断标志物，并与患者预后相关。
2. **《PRH2调控乳腺癌细胞侵袭的分子机制研究》**
- 作者：Smith J, et al.
- 摘要：利用PRH2抗体进行Western blot和免疫荧光实验，证实PRH2通过激活Wnt信号通路促进乳腺癌细胞迁移和侵袭，抗体特异性验证为机制研究提供关键工具。
3. **《PRH2抗体在斑马鱼胚胎发育中的功能验证》**
- 作者：Chen X, et al.
- 摘要：研究采用PRH2抗体进行斑马鱼胚胎原位杂交和蛋白定位，发现PRH2在中枢神经系统发育中起重要作用，抗体特异性阻断实验进一步验证其功能。
(注：以上文献为模拟示例，实际文献需通过PubMed或Google Scholar检索关键词“PRH2 antibody”、“proline-rich homeodomain 2”等获取。)
The PRH2 antibody targets the Proline-Rich Protein HaeIII Subfamily 2 (PRH2), a member of the proline-rich salivary protein family encoded by the *PRH2* gene. These proteins are primarily expressed in salivary glands and play roles in oral lubrication, microbial defense, and enamel pellicle formation. PRH2. specifically, contributes to tooth enamel maturation by binding to calcium ions and regulating mineral deposition. Its genetic variants are associated with dental conditions like amelogenesis imperfecta, characterized by defective enamel formation.
Antibodies against PRH2 are valuable tools in dental and oral biology research. They enable the detection and localization of PRH2 in tissues, aiding studies on salivary protein functions, enamel biomineralization, and oral microbiota interactions. Commercially available PRH2 antibodies are typically developed in animal hosts (e.g., rabbits) using immunogenic peptide sequences, and their specificity is validated via Western blotting, immunohistochemistry, or ELISA. Recent studies also explore PRH2's potential as a biomarker for oral diseases or systemic conditions affecting mineral metabolism. Challenges include cross-reactivity with homologous proteins (e.g., PRH1) due to sequence similarities, necessitating rigorous validation. Ongoing research focuses on clarifying PRH2's mechanistic roles in enamel pathologies and its interactions with other enamel matrix proteins.
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