| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | HOX2; HU-1; HOX2A; Hox2.1; HHO.C10 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human HOXB5 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3-4条关于HOXB5抗体的参考文献示例(注：文献信息为模拟，仅供参考)：
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1. **文献名称**：HOXB5 Expression in Colorectal Cancer and Its Prognostic Implications
**作者**：Zhang Y, et al.
**摘要**：通过免疫组化(使用HOXB5特异性抗体)分析结直肠癌组织，发现HOXB5蛋白高表达与患者生存率降低和肿瘤转移显著相关，提示其作为潜在预后标志物的价值。
2. **文献名称**：HOXB5 Regulates Self-Renewal of Lung Adenocarcinoma Stem Cells
**作者**：Lee S, et al.
**摘要**：研究利用HOXB5抗体进行Western blot和免疫荧光实验，证实HOXB5通过激活Wnt/β-catenin通路促进肺腺癌干细胞的自我更新能力，为靶向治疗提供依据。
3. **文献名称**：Developmental Role of HOXB5 in Murine Embryogenesis
**作者**：Smith J, et al.
**摘要**：通过HOXB5抗体的免疫组化分析，揭示HOXB5在小鼠胚胎发育中的时空表达模式，尤其在肺和肠道形成中起关键调控作用。
4. **文献名称**：HOXB5 as a Biomarker for Breast Cancer Metastasis
**作者**：Wang L, et al.
**摘要**：使用HOXB5抗体检测乳腺癌组织样本，发现HOXB5蛋白表达与淋巴结转移和远处转移显著相关，提示其可作为乳腺癌侵袭性的预测指标。
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建议通过PubMed、Web of Science等数据库搜索真实文献，关键词：**HOXB5 antibody**、**HOXB5 immunohistochemistry**、**HOXB5 protein expression**。
The HOXB5 antibody is a crucial tool in studying the HOXB5 protein, a member of the homeobox (HOX) gene family. HOX genes encode transcription factors critical for embryonic development, particularly in establishing body axis patterning and organogenesis. HOXB5. located on chromosome 17q21.3. contains a conserved homeodomain that binds DNA to regulate target gene expression. It plays roles in cell differentiation, proliferation, and tissue-specific development, including lung, gut, and hematopoietic system formation. Dysregulation of HOXB5 has been linked to cancers (e.g., lung, colorectal, breast) and developmental disorders.
The HOXB5 antibody enables researchers to detect and quantify HOXB5 protein levels in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). It aids in exploring HOXB5's spatial-temporal expression, its interaction networks, and its role in disease mechanisms. Commercially available antibodies are typically raised in rabbits or mice using synthetic peptides or recombinant proteins as immunogens. Validation includes testing for specificity (knockout controls), sensitivity, and cross-reactivity. Applications span developmental biology, cancer research, and stem cell studies, with emerging interest in HOXB5 as a potential diagnostic or prognostic biomarker. Proper antibody selection and validation are essential to ensure experimental reproducibility.
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