| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | HT022; C11orf3; C15orf24; ORF1-FL1 |
| WB Predicted band size | 26 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human EMC7 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于EMC7抗体的3篇虚构参考文献示例(基于常见研究方向，非真实文献)：
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1. **文献名称**：*EMC7 Antibody-Based Detection of Endoplasmic Reticulum Stress in Hepatocellular Carcinoma*
**作者**：Li X, Wang Y, et al.
**摘要**：本研究利用特异性EMC7抗体，通过免疫组化分析肝癌组织中EMC7蛋白表达水平，发现其高表达与内质网应激激活及患者不良预后显著相关，提示EMC7可能作为肝癌治疗的潜在靶点。
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2. **文献名称**：*EMC7 Modulates Aβ Production in Alzheimer’s Disease Models: Insights from Knockdown and Antibody Staining*
**作者**：Smith JL, Rodriguez M, et al.
**摘要**：通过siRNA敲低EMC7并结合抗体免疫荧光技术，发现EMC7通过影响γ-分泌酶定位调控β淀粉样蛋白(Aβ)生成，为阿尔茨海默病的分子机制提供了新视角。
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3. **文献名称**：*Development of a High-Affinity EMC7 Monoclonal Antibody for Functional Proteomics Studies*
**作者**：Chen H, Tanaka K, et al.
**摘要**：报道了一种新型EMC7单克隆抗体的开发与验证，该抗体在Western blot和Co-IP实验中表现出高特异性，成功用于解析EMC3-EMC6-EMC7复合物在内质网蛋白折叠中的相互作用网络。
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注：以上文献为模拟内容，实际引用需以真实出版物为准。建议通过PubMed或Web of Science检索关键词“EMC7 antibody”获取最新研究。
The EMC7 (Endoplasmic Reticulum Membrane Protein Complex Subunit 7) antibody is a tool used to study the EMC complex, a conserved multi-subunit transmembrane protein assembly located in the endoplasmic reticulum (ER). First identified through proteomic studies, the EMC is implicated in membrane protein biogenesis, particularly in the folding, assembly, and quality control of integral membrane proteins. EMC7. one of its core subunits, plays a structural role in maintaining complex stability and facilitating interactions with client proteins. Research suggests EMC7 contributes to ER-associated degradation (ERAD) pathways and modulates ER stress responses.
Antibodies targeting EMC7 enable researchers to investigate its expression, localization, and interactions via techniques like Western blotting, immunofluorescence, and co-immunoprecipitation. Studies have linked EMC7 dysregulation to diseases such as cancer, neurodegenerative disorders, and metabolic syndromes, where ER homeostasis is disrupted. For example, elevated EMC7 levels have been observed in certain tumors, potentially reflecting adaptive ER stress mechanisms in proliferating cells. Additionally, EMC7's role in viral replication, particularly for flaviviruses, highlights its broader cellular significance. As a relatively understudied protein, EMC7 antibodies remain critical for unraveling its precise molecular functions and therapeutic potential in pathological contexts.
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