首页 / 产品 / 抗体 / 一抗

Rabbit Polyclonal LDAH Antibody

  • 中文名： LDAH抗体
  • 别    名： hLDAH; C2orf43
货号: IPDX12993
Price： ￥1180
数量：
大包装询价

验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/50-1/300 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/5000-1/10000 Human,Mouse,Rat

产品详情

AliaseshLDAH; C2orf43
WB Predicted band size37 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenSynthetic peptide of human LDAH
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

+ +

参考文献

以下是关于LDAH(假设为脂代谢相关蛋白)抗体的示例文献摘要。**请注意，这些文献为虚构示例，仅用于演示格式，实际研究中可能需要查阅具体数据库**：

---

1. **文献名称**：*LDAH Antibody Development and Its Role in Lipid Droplet Dynamics*

**作者**：Smith J, et al.

**摘要**：本研究开发了针对LDAH蛋白的高特异性单克隆抗体，用于探究其在脂滴形成与分解中的功能。实验表明，LDAH抗体通过抑制蛋白-脂质相互作用，显著减少肝细胞脂滴积累，提示其作为代谢疾病治疗靶点的潜力。

2. **文献名称**：*LDAH Gene Mutation Screening Using Immunoblotting with Novel Polyclonal Antibodies*

**作者**：Lee H, et al.

**摘要**：研究团队设计了一种新型多克隆LDAH抗体，用于检测遗传性代谢紊乱患者的LDAH蛋白表达水平。结果发现，部分患者存在LDAH突变导致的蛋白功能缺失，为疾病诊断提供了分子依据。

3. **文献名称**：*LDAH Overexpression in Hepatocellular Carcinoma: A Study with IHC Validation*

**作者**：Zhang R, et al.

**摘要**：通过免疫组化(IHC)结合LDAH抗体，本研究揭示了肝癌组织中LDAH蛋白的异常高表达，并与患者预后不良相关，提示其可能作为癌症生物标志物。

4. **文献名称**：*Structural Characterization of LDAH Protein Using Epitope-Specific Antibodies*

**作者**：Garcia M, et al.

**摘要**：利用表位特异性LDAH抗体解析了其三维结构，发现关键功能域对脂肪酸代谢酶的调控作用，为药物开发提供了结构基础。

---

**建议**：若需真实文献，请通过PubMed或Google Scholar检索关键词“LDAH antibody”或“LDAH protein function”，并筛选与您研究领域相关的文章。如为拼写误差(如实际指LDHA/LDH)，需调整关键词重新检索。

背景信息

The LDAH (Lipoid proteinosis of Urbach-Wiethe disease-associated protein) antibody is primarily associated with studying the pathogenesis of lipoid proteinosis, a rare autosomal recessive disorder also known as Urbach-Wiethe disease. This condition is linked to mutations in the ECM1 gene, which encodes extracellular matrix protein 1 (ECM1), crucial for skin integrity, angiogenesis, and tissue remodeling. LDAH, though not directly synonymous with ECM1. is often referenced in research exploring ECM1 dysfunction. Patients with lipoid proteinosis exhibit hyaline material deposition in skin, mucous membranes, and brain tissues, leading to symptoms like hoarseness, skin thickening, and neurological abnormalities. Antibodies targeting LDAH-related proteins (e.g., ECM1) are used to detect protein expression patterns, assess tissue pathology, and investigate disease mechanisms. Such antibodies enable immunohistochemical analysis of biopsy samples, aiding diagnosis and research into therapeutic strategies. Additionally, they help elucidate ECM1's role in maintaining basement membrane structure and its interaction with extracellular components. Understanding LDAH-associated pathways may provide insights into broader connective tissue disorders and potential targeted therapies.

客户数据及评论

折叠内容

大包装询价

×