| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/20-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | SOGA; KIAA0889; C20orf117 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human SOGA1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于SOGA1抗体的3篇参考文献，按简单格式列举：
1. **文献名称**: *SOGA1 inhibits tumor proliferation via integrin αvβ3 signaling in breast cancer*
**作者**: Zhang Y, et al.
**摘要**: 研究通过Western blot和免疫组化使用SOGA1抗体，发现SOGA1通过抑制整合素信号通路抑制乳腺癌细胞增殖和转移。
2. **文献名称**: *SOGA1 deficiency promotes metabolic syndrome via mTORC1 activation*
**作者**: Li H, et al.
**摘要**: 利用SOGA1抗体在小鼠模型中发现，SOGA1缺失通过激活mTORC1通路导致糖代谢异常和脂肪堆积，提示其与代谢综合征相关。
3. **文献名称**: *SOGA1 interacts with AMPK and regulates cellular energy homeostasis*
**作者**: Wang X, et al.
**摘要**: 通过免疫共沉淀(使用SOGA1抗体)证实SOGA1与AMPK直接结合，调控能量应激下的细胞自噬和凋亡，影响肿瘤微环境。
4. **文献名称**: *Clinical significance of SOGA1 expression in colorectal cancer*
**作者**: Chen R, et al.
**摘要**: 基于SOGA1抗体的组织芯片分析显示，SOGA1低表达与结直肠癌患者预后不良相关，可能作为潜在生物标志物。
(注：以上文献信息为示例，实际引用需核实真实论文数据。)
SOGA1 (Suppressor of Glucose, Autophagy Associated 1) is a protein implicated in metabolic regulation and autophagy. It was initially identified as a tumor suppressor due to its role in inhibiting the mammalian target of rapamycin (mTOR) pathway, a key regulator of cell growth and autophagy. SOGA1 is encoded by the SOGA1 gene, which is evolutionarily conserved and expressed in various tissues, including the liver, brain, and skeletal muscle. The protein interacts with components of the insulin signaling pathway, suggesting a connection to glucose metabolism and insulin resistance. Research has shown that SOGA1 expression is downregulated in certain cancers, such as colorectal and breast cancer, correlating with disease progression and poor prognosis.
SOGA1 antibodies are critical tools for studying its function, localization, and expression patterns. These antibodies are typically developed against specific epitopes, such as the N-terminal or C-terminal regions of the human SOGA1 protein, and validated for applications like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). Studies using SOGA1 antibodies have revealed its cytoplasmic localization and involvement in stress-induced autophagy. Additionally, SOGA1 has been linked to neurodegenerative diseases, where dysregulated autophagy contributes to pathology. The antibody’s specificity is often confirmed using knockout cell lines or siRNA-mediated silencing. Ongoing research aims to clarify SOGA1’s precise molecular mechanisms and therapeutic potential in metabolic disorders and cancer.
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