| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/30-1/150 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | C18orf26 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human DYNAP |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是关于DYNAP抗体的参考文献示例，包含文献名称、作者及摘要概述：
---
1. **"Dynamin-Associated Protein (DYNAP) Antibody Characterization in Neuronal Membrane Trafficking"**
*作者：Lee, J., & Smith, T.R.*
**摘要**：本研究验证了DYNAP抗体的特异性，证实其在免疫印迹和免疫荧光中对神经元动态蛋白复合物的检测能力，揭示了DYNAP在突触囊泡循环中的作用。
2. **"DYNAP Antibody Reveals Novel Roles in Cancer Cell Endocytosis"**
*作者：Garcia, M., et al.*
**摘要**：利用DYNAP抗体分析肿瘤细胞中动态蛋白的表达水平，发现其与内吞效率及药物摄取相关，为靶向治疗提供新思路。
3. **"Development of a High-Affinity DYNAP Monoclonal Antibody for Live-Cell Imaging"**
*作者：Chen, X., et al.*
**摘要**：报道一种新型DYNAP单克隆抗体的开发，适用于活细胞动态成像，成功追踪了动态蛋白在胞质分裂中的实时定位变化。
4. **"DYNAP Antibody-Based Screening Identifies Neurodevelopmental Disorder Biomarkers"**
*作者：Wang, H., et al.*
**摘要**：通过DYNAP抗体筛选患者样本，发现动态蛋白复合物异常与神经发育障碍相关，为疾病诊断提供潜在标志物。
---
*注：以上文献为示例性质，实际研究中请根据具体需求检索权威数据库(如PubMed)获取真实文献。*
DYNAP (Dynamic Activity-regulated Phosphoprotein) antibodies are essential tools in neuroscience research, particularly for studying neuronal activity and plasticity. They target activity-dependent proteins expressed in neurons following synaptic activation, such as immediate-early genes (IEGs) like c-Fos, Arc, or FosB. These proteins serve as biomarkers for mapping neural circuits activated during specific behaviors, learning, or sensory experiences.
DYNAP antibodies enable the visualization and quantification of activated neurons via immunohistochemistry, immunofluorescence, or Western blot. Their utility lies in their ability to capture transient, activity-driven molecular changes with high spatial resolution. For instance, c-Fos expression peaks 1–2 hours post-stimulation, making DYNAP antibodies critical for tracing temporal patterns of neural activation.
These antibodies are widely used in studies on memory formation, addiction, stress responses, and neurological disorders. By identifying neurons responsive to stimuli or pathological states, researchers can dissect functional connectivity and plasticity mechanisms. Compared to electrophysiological methods, DYNAP-based approaches offer a broader, histology-compatible snapshot of network-level activity.
Recent advancements include multiplexing DYNAP antibodies with other markers (e.g., calcium indicators) to correlate molecular activity with real-time physiological data. Challenges remain in optimizing specificity and reducing background noise, but ongoing refinements continue to enhance their reliability. Overall, DYNAP antibodies bridge molecular and systems neuroscience, providing insights into how dynamic neuronal activity translates into adaptive or maladaptive brain functions.
×
