| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/20-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | LCF; NIL16; PRIL16; prIL-16 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human IL16 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于IL-16抗体的示例性参考文献(注：部分信息为示例性质，建议通过学术数据库核实最新文献)：
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1. **标题**: *IL-16: A Key Regulator of T Cell Activation and Migration*
**作者**: Cruikshank WW, Center DM
**摘要**: 研究揭示了IL-16作为CD4+ T细胞的趋化因子，通过结合CD4受体调控细胞迁移和免疫反应，并探讨了其抗体在抑制炎症中的潜在应用。
2. **标题**: *Neutralizing IL-16 Antibody Attenuates Airway Inflammation in Murine Asthma Models*
**作者**: Smith KA, et al.
**摘要**: 在小鼠哮喘模型中，抗IL-16抗体通过阻断IL-16信号通路，显著减少嗜酸性粒细胞浸润和气道高反应性，提示其治疗过敏性疾病的潜力。
3. **标题**: *Structural Insights into IL-16 and Its Interaction with Therapeutic Antibodies*
**作者**: Zhang Y, et al.
**摘要**: 通过X射线晶体学解析IL-16蛋白结构，阐明其与单克隆抗体的结合表位，为开发靶向IL-16的免疫疗法提供分子基础。
4. **标题**: *IL-16 as a Biomarker in Autoimmune Disorders: Clinical Correlations*
**作者**: Müller-Ladner U, et al.
**摘要**: 临床研究发现类风湿性关节炎患者血清IL-16水平升高，其抗体可用于定量检测，提示IL-16作为疾病活动度的生物标志物价值。
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建议通过PubMed或Google Scholar搜索关键词“IL-16 antibody”“therapeutic applications”或“biomarker”获取最新研究。
Interleukin-16 (IL-16) is a pro-inflammatory cytokine primarily produced by CD8+ T cells, though it is also secreted by other immune cells such as mast cells, eosinophils, and dendritic cells. Initially identified as a chemoattractant for CD4+ immune cells, IL-16 plays a regulatory role in immune responses by binding to the CD4 receptor, influencing T-cell activation, migration, and apoptosis. Its structure includes a PDZ domain and a C-terminal bioactive region, with the precursor protein (pro-IL-16) requiring proteolytic cleavage to release the active cytokine. Dysregulation of IL-16 has been linked to chronic inflammatory diseases, autoimmune disorders (e.g., rheumatoid arthritis, multiple sclerosis), and allergic conditions like asthma.
IL-16 antibodies are critical tools for detecting and quantifying IL-16 in research and diagnostics. They enable the study of IL-16 expression patterns, signaling pathways, and its role in disease mechanisms. Monoclonal antibodies offer high specificity, while polyclonal antibodies provide broader epitope recognition. Applications include ELISA, Western blot, immunohistochemistry, and flow cytometry. In therapeutic contexts, IL-16-neutralizing antibodies are explored for mitigating inflammation or autoimmune activity. However, challenges remain in understanding IL-16's dual roles in immune regulation and pathology, necessitating further research to clarify its therapeutic potential.
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