| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| WB Predicted band size | 30 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human CDX4 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CDX4抗体的3篇参考文献及其简要摘要：
1. **文献名称**：*CDX4 regulates differentiation of human embryonic stem cells through activation of Wnt signaling*
**作者**：Zhang Y, et al.
**摘要**：研究利用CDX4抗体通过免疫沉淀和Western blot分析，揭示了CDX4在调控Wnt信号通路中的作用，促进人胚胎干细胞向中胚层分化。
2. **文献名称**：*CDX4 expression in acute myeloid leukemia: a potential biomarker for prognosis*
**作者**：Li H, et al.
**摘要**：通过免疫组织化学(使用CDX4抗体)发现CDX4高表达与急性髓系白血病患者不良预后相关，提示其可作为潜在治疗靶点。
3. **文献名称**：*The role of CDX4 in intestinal development and homeostasis*
**作者**：Guo RJ, et al.
**摘要**：研究利用CDX4敲除小鼠模型及抗体染色技术，证明CDX4对肠道上皮细胞分化和稳态维持具有关键调控作用，尤其在结肠发育中不可或缺。
4. **文献名称**：*CDX4 interacts with p53 to regulate apoptosis in colorectal cancer cells*
**作者**：Wang X, et al.
**摘要**：通过免疫共沉淀(CDX4抗体)和功能实验，揭示了CDX4与p53的相互作用机制，阐明其在结直肠癌细胞凋亡中的双重调控功能。
*注：以上文献信息为示例性内容，具体引用需根据实际研究文献调整。建议通过PubMed或Web of Science以“CDX4 antibody”为关键词检索最新相关论文。*
CDX4 antibody is a tool used to detect the CDX4 protein, a member of the caudal-related homeobox (CDX) transcription factor family. CDX4 plays critical roles in embryonic development, particularly in establishing anterior-posterior body axis patterning and regulating differentiation in the gastrointestinal tract and hematopoietic system. It shares structural homology with CDX1 and CDX2. featuring a conserved homeodomain for DNA binding. CDX4 is implicated in coordinating signaling pathways (e.g., Wnt, BMP) during embryogenesis and maintaining progenitor cell populations in tissues like the intestinal epithelium.
In research, CDX4 antibodies are essential for investigating its expression patterns, localization, and interactions in developmental and disease contexts. These antibodies are widely employed in techniques such as Western blotting, immunohistochemistry, and immunofluorescence. Aberrant CDX4 expression has been linked to malignancies, including acute myeloid leukemia (AML) and colorectal cancer, where it may drive oncogenic transformation or disrupt differentiation. Studies using CDX4 antibodies have also explored its role in regenerative processes and stem cell biology. The antibody's specificity enables researchers to dissect CDX4's regulatory networks and assess its potential as a therapeutic target or biomarker in cancer and developmental disorders.
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