关键信息
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基因名
AURORA B
- 应用
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别名
AIM1; AIK2; ARK2; AurB; IPL1; STK1; STK12; STK5; Serine/Threonine Kinase 12; Aurora-1; Aurora-and IPL1-like midbody-associated protein 1; Aurora/IPL1-related kinase 2
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种属
Rat
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O55099
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表达区间
Gly92~Pro339
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分子量
33kD
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
AURORA B, a serine/threonine kinase, is a crucial component of the chromosomal passenger complex (CPC) and plays a pivotal role in cell division, particularly during mitosis. Its main functions include regulating spindle assembly, chromosome alignment, and ensuring proper segregation during anaphase. Dysregulation of AURORA B expression or activity is linked to various cancers, making it a significant target for therapeutic interventions. Researchers have focused on characterizing the structure and function of AURORA B and its interactions with other cell cycle proteins to better understand its role in cell division. The study of AURORA B involves not only its catalytic function but also the dynamics of its localization and how it is regulated throughout the cell cycle. Recent advances in protein engineering and crystallography have facilitated the elucidation of its molecular structure, revealing insights into its activation mechanisms and how it interacts with inhibitors. Given its role in tumorigenesis, AURORA B is of great interest in the development of targeted cancer therapies, with inhibitors being explored in clinical trials. Understanding the biochemical pathways involving AURORA B is essential for developing novel strategies to combat cancer, highlighting the importance of ongoing research in this area.
