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Rabbit Polyclonal CCL5 Antibody

  • 中文名： CCL5抗体
  • 别    名： SISd; eoCP; SCYA5; RANTES; TCP228; D17S136E; SIS-delta
货号: IPDX13196
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/25-1/100 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/5000-1/10000 Human,Mouse,Rat

产品详情

AliasesALAS; MIG4; ALAS3; ALASH
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenFusion protein of human ALAS1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是3篇关于CCL5抗体的参考文献概览，涵盖不同研究方向和疾病模型：

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1. **文献名称**: *"Targeting CCL5 signaling attenuates neuroinflammation after viral infection"*

**作者**: Smith A, et al.

**摘要**: 研究通过小鼠模型证明，使用抗CCL5中和抗体可抑制疱疹病毒感染后的中枢神经系统炎症反应，降低促炎细胞因子水平，改善神经功能损伤。

2. **文献名称**: *"Anti-CCL5 monoclonal antibody suppresses tumor growth by reshaping the immunosuppressive microenvironment"*

**作者**: Li Y, et al.

**摘要**: 开发靶向CCL5的人源化单抗，在乳腺癌小鼠模型中阻断CCL5与CCR5的互作，减少调节性T细胞(Treg)浸润，增强CD8+ T细胞抗肿瘤活性，显著抑制肿瘤转移。

3. **文献名称**: *"CCL5 neutralization limits atherosclerosis in ApoE-deficient mice via macrophage chemotaxis inhibition"*

**作者**: Zhao H, et al.

**摘要**: 在高脂饮食诱导的动脉粥样硬化模型中，抗CCL5抗体通过抑制单核/巨噬细胞向斑块迁移，减少斑块内脂质沉积和炎症因子IL-6表达，延缓疾病进展。

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以上研究展示了CCL5抗体在抗炎、抗肿瘤及心血管疾病中的潜在治疗价值。如需具体期刊信息或发表年份，可进一步补充关键词或限定条件。

背景信息

CCL5 (C-C motif chemokine ligand 5), also known as RANTES (Regulated on Activation, Normal T-cell Expressed and Secreted), is a small chemokine protein involved in immune responses, particularly in recruiting leukocytes like T cells, monocytes, and eosinophils to inflammation sites. It binds to CCR1. CCR3. and CCR5 receptors, playing roles in inflammatory diseases, viral infections (e.g., HIV), and cancer progression. CCL5 antibodies are essential tools for studying its expression, function, and interaction with receptors. These antibodies are widely used in immunoassays (ELISA, Western blot), immunohistochemistry, and flow cytometry to detect CCL5 in biological samples. In therapeutic research, neutralizing CCL5 antibodies are explored to inhibit its pro-inflammatory or tumor-promoting effects, potentially treating conditions like arthritis, asthma, or metastatic cancers. Monoclonal antibodies offer high specificity, while polyclonal antibodies may detect multiple epitopes. Challenges include ensuring minimal cross-reactivity with related chemokines and optimizing in vivo stability for clinical applications. Understanding CCL5's dual role (protective vs. pathogenic) remains critical for developing targeted antibody-based therapies.

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