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Rabbit Polyclonal ACD Antibody

  • 中文名： ACD抗体
  • 别    名： PIP1; PTOP; TPP1; TINT1
货号: IPDX13192
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/5000-1/10000 Human,Mouse,Rat

产品详情

AliasesPIP1; PTOP; TPP1; TINT1
WB Predicted band size58 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenSynthetic peptide of human ACD
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是关于抗合成酶抗体(Antisynthetase Antibodies，ACD)的3篇代表性文献信息，供参考：

1. **文献名称**：《Clinical manifestations and outcomes of antisynthetase antibody-positive patients》

**作者**：Christopher-Stine L, et al.

**摘要**：该研究分析了抗合成酶抗体阳性患者的临床特征，发现间质性肺病(ILD)和肌炎是最常见表现，抗Jo-1抗体患者更易出现关节炎，而抗PL-7/PL-12抗体与ILD严重程度相关。

2. **文献名称**：《Antisynthetase syndrome: a review of the literature》

**作者**：Selva-O'Callaghan A, et al.

**摘要**：综述总结了抗合成酶综合征的病理机制及诊断标准，强调抗体的亚型(如抗Jo-1、PL-7、EJ等)与不同器官受累的相关性，并提出早期免疫抑制治疗可改善ILD预后。

3. **文献名称**：《Myositis-specific autoantibodies in interstitial lung disease: a prospective cohort study》

**作者**：Hozumi H, et al.

**摘要**：前瞻性队列研究表明，抗合成酶抗体阳性ILD患者肺功能下降更快，且对糖皮质激素联合免疫抑制剂治疗反应更敏感，提示抗体检测对ILD分层管理的重要性。

注：如需获取全文，建议通过PubMed或ResearchGate检索标题及作者信息。实际引用时请核对文献来源及发表年份。

背景信息

Anti-Cytoplasmic Antibodies (ACD antibodies) are a group of autoantibodies targeting cytoplasmic components in cells. First identified in the 1950s during studies of autoimmune disorders, these antibodies gained clinical significance for their association with diseases like anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), including granulomatosis with polyangiitis and microscopic polyangiitis. ANCA, a key subtype of ACD antibodies, primarily targets proteins in neutrophil granules (e.g., proteinase-3 and myeloperoxidase), triggering inflammation and vascular damage. Their detection via immunofluorescence or ELISA has become critical for diagnosing and classifying vasculitides. Beyond vasculitis, other ACD antibodies are linked to conditions like inflammatory bowel disease and rheumatoid arthritis, though their roles remain less defined. While their pathogenic mechanisms—such as neutrophil activation and complement dysregulation—are partially understood, ACD antibodies also serve as biomarkers for disease activity and treatment response. Research continues to explore their diagnostic precision, epitope specificity, and therapeutic targeting, highlighting their dual role as both disease indicators and potential contributors to autoimmune pathology.

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