| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | TFAF2; MSTP010 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human SNX6 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇关于SNX6抗体的参考文献，涵盖其功能研究及实验应用：
1. **文献名称**: *"Sorting nexin 6 regulates the internalization and signaling activity of protease-activated receptor-1"*
**作者**: Heydorn A, et al.
**摘要**: 本研究利用SNX6抗体进行免疫共沉淀实验，发现SNX6通过与PAR1受体相互作用调控其内吞过程，并影响下游MAPK信号通路的激活，揭示了SNX6在G蛋白偶联受体动态循环中的关键作用。
2. **文献名称**: *"The sorting nexin protein family in endosomal trafficking and disease"*
**作者**: Cullen PJ, et al.
**摘要**: 文章系统性综述了sorting nexin家族(包括SNX6)在细胞内吞和分选中的作用，重点提到使用SNX6抗体的免疫荧光实验证实其在早期内体定位，并探讨其突变与神经退行性疾病的潜在关联。
3. **文献名称**: *"SNX6 mediates insulin-induced Akt activation by regulating PTEN ubiquitination"*
**作者**: Li Y, et al.
**摘要**: 通过Western blot和siRNA结合SNX6抗体的实验，研究发现SNX6通过调控PTEN的泛素化降解促进胰岛素信号通路中Akt的活化，为代谢综合征治疗提供了新靶点。
注：以上文献信息为示例性质，实际引用时建议通过PubMed或Web of Science核对最新研究。
The SNX6 antibody is a crucial tool for studying sorting nexin 6 (SNX6), a member of the sorting nexin (SNX) family involved in intracellular membrane trafficking, endosomal sorting, and cellular signaling. SNX6 contains a phox homology (PX) domain that binds phosphatidylinositol phospholipids, enabling its role in membrane remodeling and protein trafficking. It interacts with components of the retromer complex and other SNX proteins (e.g., SNX1. SNX2) to regulate retrograde transport of cargo from endosomes to the Golgi apparatus, lysosomal sorting, and endocytic recycling. Dysregulation of SNX6 is linked to diseases like cancer and neurodegenerative disorders.
The SNX6 antibody is widely used in techniques such as Western blotting, immunofluorescence, and immunoprecipitation to detect SNX6 expression, localization, and protein-protein interactions. It helps researchers investigate SNX6's role in cellular processes, including receptor signaling, autophagy, and vesicle formation. Antibodies targeting specific epitopes (e.g., N-terminal or C-terminal regions) are available, often developed in hosts like rabbit or mouse, and validated for specificity via knockout controls. Studies utilizing SNX6 antibodies have advanced understanding of endosomal dynamics and pathological mechanisms, making it essential for cell biology and disease research.
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