| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | CK1gamma1 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human CSNK1G1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CSNK1G1抗体的3篇文献示例(注：文献信息为模拟内容，实际引用需检索数据库)：
1. **文献名称**：*"CSNK1G1 regulates Wnt/β-catenin signaling through phosphorylation of LRP6"*
**作者**：Zhang Y, et al.
**摘要**：研究利用CSNK1G1抗体通过免疫共沉淀技术，揭示了该激酶通过磷酸化LRP6受体调控Wnt信号通路的分子机制。
2. **文献名称**：*"Expression profiling of casein kinase 1 gamma 1 (CK1γ1) in colorectal cancer"*
**作者**：Li H, et al.
**摘要**：通过Western blot和免疫组化(使用CSNK1G1特异性抗体)，发现CSNK1G1在结直肠癌中高表达，并与患者预后不良相关。
3. **文献名称**：*"Role of CSNK1G1 in circadian clock regulation: Insights from antibody-mediated depletion experiments"*
**作者**：Miller R, et al.
**摘要**：利用CSNK1G1抗体进行蛋白敲低实验，证实其在哺乳动物生物钟调控中通过磷酸化核心时钟蛋白PER2发挥作用。
如需真实文献，建议在PubMed或Google Scholar检索关键词：**"CSNK1G1 antibody"**或**"CK1 gamma 1 kinase antibody"**。
The CSNK1G1 antibody targets casein kinase 1 gamma 1 (CK1γ1), a member of the CK1 serine/threonine kinase family. CK1γ1. encoded by the *CSNK1G1* gene, plays roles in Wnt/β-catenin signaling, circadian rhythm regulation, and cell proliferation. It phosphorylates key substrates like Dishevelled (DVL) to modulate Wnt pathway activity, influencing embryonic development and tissue homeostasis. Aberrant CK1γ1 expression is linked to cancers, neurodegenerative diseases, and metabolic disorders, making it a research focus for therapeutic targeting.
CSNK1G1 antibodies are typically monoclonal or polyclonal, generated using immunogenic peptides from conserved regions of the human CK1γ1 protein. They are validated for applications like Western blotting, immunoprecipitation, immunofluorescence, and immunohistochemistry. Specificity is confirmed via knockout controls or siRNA knockdown. These antibodies aid in studying CK1γ1’s localization, expression levels, and interactions in disease models. Commercial variants often include species reactivity details (human, mouse, rat) and compatibility with specific experimental conditions. Researchers use them to explore CK1γ1’s regulatory mechanisms and its potential as a biomarker or drug target. Proper validation remains critical due to kinase family homology and splice variant diversity.
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