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Rabbit Monoclonal TNNI1 Antibody

  • 中文名： TNNI1抗体
  • 别    名： SSTNI; TNN1; Tnni1; Troponin I;;TNNI1
货号: IPDX18243
Price： ￥1280
数量：
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验证与应用

应用及物种
WB 1/1000-1/2000 Human,Mouse,Rat
IF 1/20-1/50 Human,Mouse,Rat
IHC 1/100-1/200 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesSSTNI; TNN1; Tnni1; Troponin I;;TNNI1
WB Predicted band size22 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenA synthesized peptide derived from human TNNI1
FormulationPurified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

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参考文献

以下是关于TNNI1抗体的3篇代表性文献的简要总结(注：文献信息为模拟示例，实际引用需根据真实文献调整)：

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1. **文献名称**：*"Characterization of a Monoclonal Antibody Specific for Slow Skeletal Muscle Troponin I (TNNI1)"*

**作者**：Smith A, et al.

**摘要**：研究报道了一种特异性识别TNNI1的单克隆抗体的开发与验证。通过免疫印迹和免疫组化实验，证实该抗体在慢骨骼肌组织中高特异性结合TNNI1.不与其他肌钙蛋白亚型交叉反应，为研究骨骼肌疾病提供了可靠工具。

2. **文献名称**：*"TNNI1 as a Biomarker in Congenital Myopathies: Insights from Immunohistochemical Analysis"*

**作者**：Lee J, et al.

**摘要**：通过TNNI1抗体对先天性肌病患者的肌肉活检样本进行分析，发现TNNI1表达水平与慢肌纤维的病理改变显著相关，提示其可作为评估肌纤维分化和疾病进展的潜在标志物。

3. **文献名称**：*"Comparative Study of TNNI1 Expression in Vertebrate Muscle Development"*

**作者**：Wang X, et al.

**摘要**：利用TNNI1抗体比较斑马鱼、小鼠和人类胚胎期骨骼肌发育中的表达模式，发现TNNI1在慢肌纤维分化中高度保守，其动态表达与肌肉功能成熟密切相关。

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如需具体文献，建议通过PubMed或Web of Science检索关键词"TNNI1 antibody"或结合研究背景筛选(如疾病模型、技术应用等)。实际文献可能侧重抗体开发、疾病机制或诊断应用方向。

背景信息

The TNNI1 antibody is a immunological tool designed to detect and quantify troponin I type 1 (TNNI1), a protein encoded by the TNNI1 gene in humans. TNNI1. also known as slow skeletal muscle troponin I, is a key component of the troponin complex that regulates calcium-dependent skeletal muscle contraction. It is predominantly expressed in slow-twitch (Type I) skeletal muscle fibers and plays a role in maintaining muscle tone and endurance. Research involving TNNI1 antibodies is critical for studying muscle development, function, and disorders such as congenital myopathies or muscular dystrophies. These antibodies are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to localize TNNI1 expression in tissues or assess its expression levels under pathological conditions. Notably, TNNI1 has also been investigated in certain cancers, including rhabdomyosarcoma, due to its muscle-specific expression. Commercially available TNNI1 antibodies are typically validated for specificity against human, mouse, or rat samples, with applications spanning basic research and diagnostic development. Its distinction from cardiac troponin I (TNNI3) makes it a valuable marker for differentiating skeletal muscle-specific pathologies from cardiac conditions in clinical settings.

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