关键信息
-
基因名
CUL4A-RBX1
- 应用
-
别名
Cullin-4A; CUL4A; Homo sapiens; Human
-
种属
Human
-
表达系统
Baculovirus
-
标签
Tag Free
-
纯度
Greater than 90% as determined by SDS-PAGE.
-
蛋白编号
Q13619-1 (A2-A759)&P62877
-
表达区间
Q13619-1 (A2-A759)&P62877 (M1-H108)
-
分子量
87.6 KDa/12.2 KDa
-
内毒素
< 1.0 EU per μg protein as determined by the LAL method.
-
性状
Freeze-dried powder
-
缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
-
稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
CUL4A-RBX1 is an important component of the Cullin-RING E3 ubiquitin ligase complex, which plays a critical role in regulating protein degradation and various cellular processes, including cell cycle progression, DNA repair, and response to stress. The CUL4A protein serves as a scaffold for the assembly of the E3 ligase complex, while RBX1 acts as the RING finger protein, facilitating the transfer of ubiquitin to target substrates. Dysregulation of the CUL4A-RBX1 complex has been implicated in various diseases, particularly cancer, as it can lead to the aberrant accumulation of proteins that drive tumorigenesis. Research on the CUL4A-RBX1 recombinant protein has focused on understanding its structural characteristics and functional mechanisms, which are essential for developing targeted therapies that can modulate its activity. By elucidating the role of CUL4A-RBX1 in cellular ubiquitination processes, scientists aim to identify novel therapeutic strategies to combat cancer and other diseases associated with misregulated protein homeostasis. Recent studies have also explored the potential of CUL4A-RBX1 as a biomarker for disease progression and prognosis, highlighting its relevance in translational research. Overall, the investigation of CUL4A-RBX1 recombinant protein not only enhances our understanding of the ubiquitin-proteasome system but also opens new avenues for therapeutic interventions in malignancies and other disorders linked to E3 ligase dysfunction.
