关键信息
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基因名
CHMP2B
- 应用
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别名
CHMP2.5 Chromatin-modifying protein 2b
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种属
Human
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表达系统
E. coli
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标签
N- GST
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9UQN3
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表达区间
1-213aa
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分子量
50.8 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
CHMP2B, a pivotal component of the endosomal sorting complexes required for transport (ESCRT), has garnered considerable interest in neurodegenerative disease research, particularly in relation to frontotemporal dementia (FTD). Mutations in the CHMP2B gene have been linked to familial forms of FTD, highlighting its crucial role in cellular membrane trafficking and protein degradation pathways. Recent studies suggest that misfolding and aggregation of CHMP2B may disrupt the normal functioning of the ESCRT machinery, leading to impaired autophagy and increased susceptibility to neurotoxic protein accumulation. Investigating recombinant CHMP2B proteins allows researchers to better understand the protein's structural and functional properties, as well as how mutations affect its role in cellular processes. Furthermore, this research aims to elucidate the molecular mechanisms underlying FTD and may pave the way for potential therapeutic strategies targeting the ESCRT pathway, thereby offering hope for the development of interventions that could modify disease progression in affected individuals.
