关键信息
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基因名
ADCY4
- 应用
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别名
ATP pyrophosphate-lyase 4; Adenylate cyclase type IV
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种属
Mouse
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q91WF3
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表达区间
Ile352~Val541
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分子量
27kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
ADCY4, or Adenylate Cyclase 4, is a crucial enzyme involved in the synthesis of cyclic adenosine monophosphate (cAMP), a secondary messenger that plays a significant role in various physiological processes such as neurotransmission, hormonal signaling, and metabolic regulation. Elevated interest in ADCY4 has emerged due to its association with several diseases, including heart failure, diabetes, and neurological disorders. Research has shown that ADCY4 can be modulated by G-protein coupled receptors (GPCRs), leading to diverse cellular responses. The recombinant expression of ADCY4 allows for a detailed investigation of its enzymatic activity, regulation, and interaction with other proteins and signaling pathways. Moreover, producing ADCY4 as a recombinant protein enables the exploration of its therapeutic potential, including the development of specific inhibitors or activators that could be used in treating conditions linked to dysregulated cAMP signaling. By elucidating the structure-function relationships of ADCY4 through techniques such as X-ray crystallography and molecular modeling, researchers aim to design novel drugs that can selectively target ADCY4, thereby contributing to more effective therapeutic strategies for associated diseases. Overall, the study of ADCY4 recombinant protein serves as a foundational step in understanding its role in cellular signaling and developing innovative treatments.
