关键信息
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基因名
MC3R
- 应用
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别名
MC3
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种属
Human
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表达系统
E. coli
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标签
N- His & GST
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P41968
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表达区间
Met1~Asp117
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分子量
43kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
The melanocortin 3 receptor (MC3R) is a G-protein coupled receptor that plays a crucial role in regulating energy homeostasis, appetite, and metabolism. It is primarily expressed in the central nervous system, particularly in the hypothalamus, where it influences feeding behavior and energy expenditure. Genetic studies have identified variants in the MC3R gene that are associated with obesity and metabolic disorders, highlighting its significance in energy balance and weight regulation. Given the rising prevalence of obesity and related health issues globally, understanding the functional mechanisms of MC3R has become a focal point in metabolic research. Recombinant MC3R protein studies allow scientists to investigate the receptor's structure-function relationships, signaling pathways, and interactions with endogenous ligands such as α-MSH (alpha-melanocyte-stimulating hormone). Additionally, these studies pave the way for the development of novel therapeutic approaches targeting MC3R to combat obesity and metabolic dysfunctions. Overall, the exploration of MC3R through recombinant protein techniques aims to elucidate its biological roles and therapeutic potential, contributing to the broader understanding of metabolic regulation.
