Recombinant Human NGFR protein

**Background of NGFR Recombinant Protein**

The nerve growth factor receptor (NGFR), also known as p75 neurotrophin receptor (p75NTR) or CD271. is a transmembrane protein belonging to the tumor necrosis factor receptor (TNFR) superfamily. Initially identified as a receptor for nerve growth factor (NGF), NGFR binds multiple neurotrophins, including brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3), with low affinity. It plays a dual role in regulating cell survival, apoptosis, differentiation, and axonal guidance, depending on cellular context and interactions with co-receptors like Trk tyrosine kinases. Structurally, NGFR contains cysteine-rich extracellular domains for ligand binding, a transmembrane region, and an intracellular "death domain" involved in signaling.

In the nervous system, NGFR is critical during development, influencing neuronal survival, synaptic plasticity, and neural crest cell migration. Beyond neuroscience, it is implicated in immune regulation, wound healing, and cancer. For instance, NGFR is overexpressed in certain cancers, where it may promote invasion, stemness, or therapy resistance.

Recombinant NGFR protein is engineered *in vitro* using expression systems (e.g., mammalian or bacterial cells) to produce purified, bioactive forms of the receptor. This protein retains functional domains, enabling studies on neurotrophin signaling mechanisms, receptor-ligand interactions, and downstream pathways (e.g., NF-κB or JNK). Researchers utilize it to develop therapeutic strategies, such as targeting NGFR in cancers or neuropathies. It also serves as a tool in drug screening, antibody development, and tissue engineering. Additionally, fusion constructs (e.g., NGFR-Fc) are employed to stabilize neurotrophins or track receptor localization *in vitro* and *in vivo*.

Overall, NGFR recombinant protein is a versatile resource for unraveling neurotrophic signaling complexities and advancing translational research in neurology, oncology, and regenerative medicine.