关键信息
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基因名
CRHR2
- 应用
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别名
CRFR2; CRF2; Corticotropin-releasing factor receptor 2
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种属
Rat
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
D4A5C4
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表达区间
Met1~Lys108
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分子量
15kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
Corticotropin-releasing hormone receptor 2 (CRHR2) is a key component of the hypothalamic-pituitary-adrenal (HPA) axis, playing an essential role in the body's response to stress. It primarily mediates the effects of corticotropin-releasing hormone (CRH), influencing various physiological and behavioral responses. Research has shown that CRHR2 is implicated in modulating anxiety, depression, and other stress-related disorders, making it a potential target for therapeutic interventions. The study of CRHR2 recombinant proteins has gained prominence, as these proteins can be used to elucidate receptor function, signaling pathways, and pharmacodynamics. By generating CRHR2 in recombinant systems, researchers can produce large quantities of the functional receptor, facilitating structural and functional analyses, drug discovery, and the development of CRHR2-specific ligands. The understanding of CRHR2's interactions with its ligands and downstream signaling mechanisms is crucial for interpreting its role in neurobiology, particularly in the context of stress-related pathologies. Furthermore, the exploration of CRHR2 as a therapeutic target holds promise for novel treatment strategies in mental health disorders, underscoring the importance of ongoing research in this domain.
