关键信息
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基因名
MAPK12
- 应用
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别名
ERK6; PRKM12; p38 Gamma; SAPK3; Stress-activated protein kinase 3; Extracellular signal-regulated kinase 6; Mitogen-activated protein kinase p38 gamma
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种属
Human
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P53778
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表达区间
Tyr27~Phe311
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分子量
31kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
MAPK12, also known as p38γ, is a member of the mitogen-activated protein kinase (MAPK) family, which plays a critical role in various cellular processes, including proliferation, differentiation, and response to stress signals. Unlike other MAPK family members, MAPK12 has been shown to have a unique expression pattern, predominantly found in striated muscle tissues and some types of cancer cells. Its activation is often associated with physiological responses to cellular stressors, such as inflammation and oxidative stress, making it a potential target for therapeutic interventions. Recent studies have highlighted MAPK12's involvement in various pathological conditions, including muscle disorders and cancer progression, revealing its dual role in promoting cell survival or apoptosis depending on the context. The development of recombinant MAPK12 proteins has facilitated extensive research into its functional properties, interactions with other signaling pathways, and its potential as a biomarker for disease prognosis. Understanding the specific mechanisms by which MAPK12 contributes to cellular responses may offer new insights into targeted therapies for diseases characterized by aberrant MAPK signaling. As research in this field continues to evolve, the potential for exploiting MAPK12 in clinical applications represents a promising frontier in molecular medicine.
