关键信息
-
基因名
EBNA2
- 应用
-
别名
EBNA2; BYRF1Epstein-Barr nuclear antigen 2; EBNA-2; EBV nuclear antigen 2
-
种属
Epstein-Barr virus
-
表达系统
Yeast
-
标签
N- His & C- Myc
-
纯度
Greater than 90% as determined by SDS-PAGE.
-
蛋白编号
Q69022
-
表达区间
247-454aa
-
分子量
25.9 kDa
-
内毒素
< 1.0 EU per μg protein as determined by the LAL method.
-
性状
Freeze-dried powder
-
缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
-
稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
EBNA2 (Epstein-Barr virus Nuclear Antigen 2) is a critical protein involved in the pathogenesis of Epstein-Barr virus (EBV), which is linked to various lymphoproliferative disorders and lymphomas. EBV, a member of the herpesvirus family, is one of the most common human viruses, and its association with diseases such as infectious mononucleosis and several types of cancer has garnered significant research interest. EBNA2 plays a pivotal role in the transformation of B lymphocytes, promoting cell proliferation and survival by activating several cellular genes. Its mechanism of action involves interaction with host cell transcription factors, leading to altered gene expression and oncogenic potential. The study of EBNA2 is crucial for understanding the molecular pathways underlying EBV-related malignancies and for developing targeted therapies. Recent advancements in recombinant protein technology have allowed for the production and characterization of EBNA2 in vitro, facilitating studies on its functional properties and interactions. By elucidating the structure and function of EBNA2, researchers aim to identify potential biomarkers for disease progression and therapeutic targets, thereby contributing to the broader field of viral oncology. As the global burden of EBV-associated diseases continues to rise, increasing our understanding of EBNA2's role in these processes is essential for developing novel strategies for intervention and treatment.
