关键信息
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基因名
APBB1IP
- 应用
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别名
INAG1; RIAM; RARP1; APBB1-interacting protein; Proline-rich EVH1 ligand; Rap1-GTP-interacting adapter molecule; Retinoic acid-responsive proline-rich protein
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种属
Human
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表达系统
E. coli
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标签
N- His & GST
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q7Z5R6
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表达区间
Ser188~Lys421
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分子量
58kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
APBB1IP (Amyloid Precursor Protein Binding Family B Member 1 Interacting Protein) is a protein that plays a crucial role in various cellular processes, including mitochondrial function, neuronal signaling, and regulation of amyloid precursor protein (APP) trafficking. The protein's interaction with APP has drawn significant attention in the context of Alzheimer’s disease, where impaired APP processing leads to the accumulation of amyloid-beta plaques, a hallmark of the disease. Understanding the molecular mechanisms underlying APBB1IP's function provides insights into its potential role as a therapeutic target. Recent studies have demonstrated that APBB1IP may influence neuronal survival and apoptosis through its associations with different proteins involved in apoptosis and neuroprotection. Consequently, the recombinant expression of APBB1IP can facilitate the study of its interactions and biological functions in a controlled environment, allowing for the exploration of its implications in neurodegenerative diseases. Additionally, recombinant versions of APBB1IP can be utilized in drug screening and development, providing a platform to identify compounds that can modulate its activity. Thus, research on recombinant APBB1IP not only contributes to our understanding of fundamental biological processes but also offers potential pathways for therapeutic intervention in Alzheimer's disease and related disorders.
