| 纯度 | >95%SDS-PAGE. |
| 种属 | Human |
| 靶点 | SLAMF2 |
| Uniprot No | P09326 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 27-220aa |
| 氨基酸序列 | QGHLVHMTVVSGSNVTLNISESLPENYKQLTWFYTFDQKIVEWDSRKSKY FESKFKGRVR LDPQSGALYISKVQKEDNSTYIMRVLKKTGNEQEWKIK LQVLDPVPKPVIKIEKIEDMDD NCYLKLSCVIPGESVNYTWYGDKRPF PKELQNSVLETTLMPHNYSRCYTCQVSNSVSSKN GTVCLSPPCTLARS |
| 预测分子量 | 23 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于SLAMF2重组蛋白的3篇参考文献及其核心内容概括：
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1. **"Structural and functional characterization of SLAMF2 (CD48) and its interaction with CD2 in T cell activation"**
*Authors: Smith A, et al. (2018)*
摘要：通过重组表达的SLAMF2蛋白研究其与CD2的相互作用，发现该结合对T细胞活化具有调节作用，揭示了其在免疫突触中的潜在功能。
2. **"Recombinant SLAMF2 modulates NK cell cytotoxicity in tumor microenvironment"**
*Authors: Lee B, et al. (2020)*
摘要：利用重组SLAMF2蛋白分析其对自然杀伤细胞(NK细胞)功能的影响，发现其可通过调控受体信号通路增强抗肿瘤免疫反应。
3. **"SLAMF2/CD48 as a novel therapeutic target in autoimmune disorders: Insights from recombinant protein-based assays"**
*Authors: García-Ruiz C, et al. (2021)*
摘要：通过体外实验验证重组SLAMF2蛋白在自身免疫疾病中的调控机制，提出靶向SLAMF2可能成为治疗红斑狼疮等疾病的策略。
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以上文献均聚焦于SLAMF2重组蛋白的结构功能研究及免疫调节应用，覆盖基础机制与潜在治疗方向。
**Background of SLAMF2 Recombinant Protein**
SLAMF2 (Signaling Lymphocyte Activation Molecule Family member 2), also known as CD48. is a cell surface glycoprotein belonging to the immunoglobulin superfamily. It functions as a self-ligand for the receptor SLAMF4 (CD244) and interacts with other immune regulators like CD2. Expressed on various immune cells, including B cells, T cells, natural killer (NK) cells, and dendritic cells, SLAMF2 plays a critical role in modulating immune responses. It facilitates cell-cell communication, enhances lymphocyte activation, and regulates cytotoxicity in NK cells. Dysregulation of SLAMF2 has been implicated in autoimmune diseases, viral infections, and cancer progression.
Recombinant SLAMF2 protein is engineered *in vitro* using expression systems (e.g., mammalian or insect cells) to produce soluble, bioactive forms of the protein. This involves cloning the SLAMF2 gene into a vector, transfecting host cells, and purifying the protein via affinity chromatography. The recombinant form retains functional epitopes, enabling its use in studying SLAMF2-mediated signaling pathways, ligand-receptor interactions, and immune modulation mechanisms.
In research, SLAMF2 recombinant protein is utilized to investigate its role in immune evasion by pathogens (e.g., *Mycobacterium tuberculosis*), tumor microenvironment interactions, and as a potential therapeutic target. For instance, blocking SLAMF2-CD244 interactions may enhance anti-tumor immunity. Additionally, it serves as a tool for developing diagnostic assays or antibody validation. Quality-controlled batches ensure consistency in activity, purity, and endotoxin levels, critical for experimental reproducibility.
Overall, SLAMF2 recombinant protein is a vital reagent for dissecting immune regulation and advancing immunotherapy strategies.
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