关键信息
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基因名
RAB4A
- 应用
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别名
HRES 1 / RAB4; Oncogene RAB4; Rab 4; RAB 4A; RAB4 member RAS oncogene family; Rab4a; RAB4A member RAS oncogene family; RAB4A_HUMAN; Ras related protein Rab 4A; Ras related protein Rab4A; Ras-related protein Rab-4A
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种属
Human
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表达系统
E. coli
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标签
N- GST
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P20338
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表达区间
1-218aa
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分子量
51.4 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
RAB4A is a member of the RAB GTPase family, which plays a crucial role in intracellular vesicle trafficking, particularly in the regulation of endosomal and recycling pathways. Research has indicated that RAB4A is involved in the transport of proteins and lipids within cells, facilitating their sorting and delivery to specific destinations, which is vital for maintaining cellular homeostasis. The protein is implicated in various biological processes, including immune response, neurite outgrowth, and cell adhesion. Dysregulation of RAB4A has been associated with several pathological conditions, including cancer, where altered vesicular transport can lead to enhanced cell migration and metastasis. Therefore, understanding the function and regulation of RAB4A is important for elucidating its role in health and disease. Scientists increasingly focus on the expression and purification of RAB4A recombinant protein to explore its biochemical properties, interactions with other proteins, and its functional mechanisms in cellular contexts. This research not only enhances our understanding of vesicle trafficking but also provides insights into potential therapeutic targets for diseases related to RAB4A dysregulation.
