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Rabbit Polyclonal SNX6 Antibody

  • 中文名： SNX6抗体
  • 别    名： Sorting nexin-6, TRAF4-associated factor 2, Sorting nexin-6, N-terminally processed, SNX6
货号: IPDX30431
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesSorting nexin-6, TRAF4-associated factor 2, Sorting nexin-6, N-terminally processed, SNX6
Entrez GeneID58533
WB Predicted band size46.6kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis SNX6 antibody is generated from rabbits immunized with human SNX6 recombinant protein.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于SNX6抗体的3篇参考文献的简要信息(基于公开研究整理，非真实文献)：

1. **文献名称**：*SNX6 regulates endosomal membrane trafficking and interacts with retromer complex components*

**作者**：Wassmer T, et al.

**摘要**：研究利用SNX6抗体进行免疫沉淀实验，发现SNX6与逆转运复合体(retromer)相互作用，调控细胞内吞途径的膜运输过程，影响受体蛋白的再循环。

2. **文献名称**：*Sorting nexin 6 enhances viral replication by inhibiting innate immunity via suppressing TBK1-IRF3 signaling*

**作者**：Li S, et al.

**摘要**：通过SNX6抗体的Western blot分析，揭示SNX6通过抑制TBK1-IRF3信号通路削弱宿主抗病毒免疫反应，从而促进病毒复制。

3. **文献名称**：*The role of SNX6 in amyloid precursor protein processing and Alzheimer's disease pathogenesis*

**作者**：Kim E, et al.

**摘要**：利用SNX6抗体进行免疫荧光染色，发现SNX6参与淀粉样前体蛋白(APP)的胞内运输，可能影响阿尔茨海默病的病理进程。

(注：以上文献为示例性质，实际研究中请通过学术数据库核实具体文献。)

背景信息

SNX6 (Sorting Nexin 6) is a member of the sorting nexin family, a group of proteins involved in membrane trafficking, endosomal sorting, and cellular signaling. These proteins typically contain a phox homology (PX) domain that binds phosphoinositides, enabling their association with specific membranes. SNX6 lacks a BAR domain but can heterodimerize with other BAR domain-containing sorting nexins, such as SNX1 or SNX2. to form complexes that regulate retrograde transport from endosomes to the trans-Golgi network. It also interacts with retromer complexes, influencing cargo recognition and tubule formation. SNX6 antibodies are critical tools for studying its expression, localization, and function in these processes. They are widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to explore SNX6's role in cellular pathways, including receptor recycling, lysosomal degradation, and autophagy. Dysregulation of SNX6 has been implicated in diseases such as cancer, neurodegenerative disorders, and metabolic syndromes, making these antibodies valuable for both basic research and translational studies. Commercial SNX6 antibodies are typically raised in rabbits or mice, with validation including knockout cell lines or siRNA knockdown to confirm specificity.

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