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Rabbit Polyclonal PRUNE Antibody

  • 中文名： PRUNE抗体
  • 别    名： Protein prune homolog, hPrune, Drosophila-related expressed sequence 17, DRES-17, DRES17, HTcD37, PRUNE
货号: IPDX30537
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/100-1/500 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 1/10-1/50 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesProtein prune homolog, hPrune, Drosophila-related expressed sequence 17, DRES-17, DRES17, HTcD37, PRUNE
Entrez GeneID58497
WB Predicted band size50.2kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis PRUNE antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 360-389 amino acids from the C-terminal region of human PRUNE.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于PRUNE抗体的3篇参考文献示例(文献为示例性质，非真实存在)：

1. **标题**：PRUNE Antibody Development for Targeting Metastatic Neuroblastoma

**作者**：Smith A, et al.

**摘要**：本研究开发了一种高特异性PRUNE单克隆抗体，用于检测神经母细胞瘤中PRUNE蛋白的表达水平。实验表明，PRUNE抗体通过抑制细胞迁移相关信号通路(如Rho-GTPase)，显著降低了肿瘤细胞的转移能力。

2. **标题**：PRUNE Interaction with DM2 in Breast Cancer Progression

**作者**：Chen L, et al.

**摘要**：通过免疫共沉淀结合PRUNE抗体的应用，研究发现PRUNE与DM2蛋白在乳腺癌中形成复合物，协同促进肿瘤细胞增殖和化疗耐药。抗体阻断实验提示PRUNE可能成为联合治疗的潜在靶点。

3. **标题**：PRUNE as a Prognostic Biomarker in Colorectal Cancer

**作者**：Yamamoto K, et al.

**摘要**：利用PRUNE多克隆抗体对结肠癌组织进行免疫组化分析，发现PRUNE高表达与患者预后不良及淋巴结转移显著相关。机制研究表明，PRUNE通过调控Wnt/β-catenin通路驱动上皮-间质转化(EMT)。

注：以上文献为示例，实际研究中建议通过PubMed等数据库检索真实发表论文。

背景信息

The PRUNE antibody is a tool used to study the PRUNE protein, a critical enzyme encoded by the *PRUNE1* gene in humans. Belonging to the DHH phosphoesterase family, PRUNE hydrolyzes nucleoside polyphosphates and regulates cellular processes like proliferation, migration, and signaling. It interacts with key pathways, including TGF-β and EGFR, and modulates cytoskeletal dynamics via proteins like NME1. Dysregulation of PRUNE is linked to cancer metastasis, neurodevelopmental disorders, and other pathologies. Overexpression promotes tumor invasiveness in breast, lung, and colorectal cancers, often synergizing with oncogenes like MYC. In neurodevelopment, *PRUNE1* mutations are associated with microcephaly and developmental delays. PRUNE antibodies enable detection and functional analysis in research settings, aiding investigations into its role in disease mechanisms. They are used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to assess expression levels and localization in tissues or cell lines. Additionally, PRUNE antibodies hold potential for diagnostic applications, such as identifying tumors with elevated PRUNE levels, and therapeutic exploration, including targeted inhibition strategies. Ongoing research focuses on clarifying PRUNE's diverse molecular interactions and validating its utility as a biomarker or therapeutic target.

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