关键信息
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基因名
OPRM1
- 应用
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别名
Mu-type opioid receptor(M-OR-1)(MOR-1)(Mu opiate receptor)(Mu opioid receptor)(MOP)(hMOP)
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种属
Human
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表达系统
E. coli
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标签
N- His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P35372
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表达区间
1-400aa
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分子量
47.6 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
OPRM1, or the μ-opioid receptor, is a key protein in the body's pain modulation system and plays a crucial role in mediating the effects of opioids, which are widely used for pain relief but can lead to addiction and other adverse effects. The receptor is encoded by the OPRM1 gene, which exhibits genetic polymorphisms that can influence individual responses to opioid therapy and susceptibility to addiction. Recent research has focused on the functional characterization of OPRM1, including its expression in various tissues, signaling pathways, and interactions with different ligands, including endogenous peptides and synthetic drugs. The development of recombinant OPRM1 proteins has facilitated detailed studies on receptor pharmacology, structure-function relationships, and the identification of novel compounds that can modulate receptor activity for therapeutic applications. Furthermore, understanding the molecular mechanisms underlying OPRM1 function is vital for addressing issues of opioid efficacy and safety, paving the way for more personalized medicine approaches in pain management and addiction treatment. As the opioid crisis continues to pose significant public health challenges, ongoing research into OPRM1 and its signaling pathways remains essential for developing safer and more effective analgesics that minimize the risk of dependence.
