Recombinant Human CCR4 Protein(HEK293), C- His (This can be tested only under denaturing conditions)

CCR4 (C-C chemokine receptor type 4) is a G protein-coupled receptor that plays a crucial role in immune regulation, particularly in the migration and homing of T cells. It is predominantly expressed on the surface of T-helper cells, regulatory T cells, and certain subsets of dendritic cells, where it mediates the recruitment of these immune cells to sites of inflammation and infection. CCR4 has gained significant attention in recent years due to its involvement in various pathophysiological conditions, including autoimmune diseases, allergies, and cancer. In tumor microenvironments, CCR4 is often upregulated, facilitating the escape of malignant cells from immune surveillance, thereby contributing to tumor progression and metastasis. Consequently, the CCR4 receptor represents a promising target for therapeutic interventions, particularly in the development of monoclonal antibodies and small molecule inhibitors aimed at enhancing anti-tumor immunity and improving patient outcomes. The engineering and study of CCR4 recombinant proteins allow researchers to investigate its structure, function, and interactions, enabling the identification of potential pharmacological agents that can modulate its activity. Understanding the signaling pathways and biological implications of CCR4 will thus provide valuable insights into designing novel immunotherapies and improving treatment strategies for CCR4-associated diseases. This makes CCR4 recombinant protein research not only relevant to basic immunology but also a critical component of applied medical research aimed at addressing significant health challenges.