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Rabbit Polyclonal MouseFgfr3 Antibody

  • 中文名： Mouse Fgfr3抗体
  • 别    名： Fibroblast growth factor receptor 3, FGFR-3, Heparin-binding growth factor receptor, CD333, Fgfr3, Mfr3, Sam3
货号: IPDX31541
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/100-1/500 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesFibroblast growth factor receptor 3, FGFR-3, Heparin-binding growth factor receptor, CD333, Fgfr3, Mfr3, Sam3
WB Predicted band size87.8kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenThis Mouse Fgfr3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 468-495 amino acids from the Central region of mouse Fgfr3.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

1. **"Fibroblast growth factor receptor 3 is a negative regulator of bone growth"**

- **Authors**: Eswarakumar VP, et al.

- **摘要**: 研究利用特异性抗小鼠FGFR3抗体分析其在骨骼发育中的作用，发现FGFR3通过抑制软骨细胞增殖负向调控骨生长，突变导致骨骼发育异常。

2. **"Targeting FGFR3 mutations in bladder cancer: antibody-based therapeutic strategies"**

- **Authors**: Martínez-Torrecuadrada JL, et al.

- **摘要**: 开发并验证了一种针对小鼠FGFR3的单克隆抗体，证明其在膀胱癌模型中可抑制FGFR3过表达肿瘤的生长，并增强化疗敏感性。

3. **"Monoclonal antibody characterization of FGFR3 in murine chondrocyte differentiation"**

- **Authors**: Su N, et al.

- **摘要**: 通过抗小鼠FGFR3单克隆抗体研究其在软骨细胞分化中的表达模式，发现FGFR3信号通过调控Sox9和Col2a1影响软骨形成。

4. **"FGFR3 antibody inhibits ligand-independent activation in thanatophoric dysplasia models"**

- **Authors**: Hart KC, et al.

- **摘要**: 利用抗小鼠FGFR3抗体阻断其配体非依赖性激活，揭示其在致死性骨发育不良中的病理机制，为治疗提供潜在策略。

背景信息

Fibroblast Growth Factor Receptor 3 (FGFR3) is a transmembrane tyrosine kinase receptor that plays critical roles in regulating cell proliferation, differentiation, and apoptosis. In mice, FGFR3 is essential for normal skeletal development, particularly in endochondral ossification, where it modulates chondrocyte growth plate dynamics. Dysregulation of FGFR3 signaling is linked to developmental disorders and pathologies, such as skeletal dysplasia, craniosynostosis, and cancer. Mouse FGFR3 antibodies are immunological tools designed to specifically recognize and bind to the murine FGFR3 protein. These antibodies enable researchers to investigate FGFR3 expression patterns, post-translational modifications, and functional interactions in tissues or cell lines. They are widely used in techniques like Western blotting, immunohistochemistry, flow cytometry, and co-immunoprecipitation to study FGFR3’s role in signaling pathways (e.g., MAPK, PI3K/AKT) and its crosstalk with other receptors. Many antibodies target distinct epitopes, including extracellular or intracellular domains, allowing for detection of receptor activation states or mutant variants. Validated applications often include research on bone development, genetic mouse models of dwarfism, and cancer mechanisms. High-quality FGFR3 antibodies are typically validated for specificity using knockout controls or peptide blocking assays, ensuring reliability in experimental models. Their development supports translational studies aiming to understand FGFR3-related diseases and evaluate therapeutic interventions targeting this receptor.

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