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Rabbit Polyclonal CDR2 Antibody

  • 中文名： CDR2抗体
  • 别    名： Cerebellar degeneration-related protein 2, Major Yo paraneoplastic antigen, Paraneoplastic cerebellar degeneration-associated antigen, CDR2, PCD17
货号: IPDX31544
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/100-1/500 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesCerebellar degeneration-related protein 2, Major Yo paraneoplastic antigen, Paraneoplastic cerebellar degeneration-associated antigen, CDR2, PCD17
Entrez GeneID1039
WB Predicted band size51.9kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis CDR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 420-448 amino acids from the C-terminal region of human CDR2.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于CDR2抗体的3篇示例文献摘要(仅供参考，非真实文献)：

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1. **文献名称**：*Anti-CDR2 Antibodies in Paraneoplastic Cerebellar Degeneration*

**作者**：Darnell RB, et al.

**摘要**：研究揭示了抗CDR2抗体在副肿瘤性小脑变性(PCD)患者中的致病作用，发现其通过靶向小脑浦肯野细胞内的CDR2蛋白，导致自身免疫性神经损伤，并与卵巢癌等肿瘤相关。

2. **文献名称**：*CDR2 as a Tumor-Associated Antigen in Breast Cancer*

**作者**：Albert ML, et al.

**摘要**：探讨CDR2在乳腺癌细胞中的异常表达，并开发了特异性抗CDR2单克隆抗体，证实其在体外可抑制肿瘤细胞增殖，提示其作为免疫治疗靶点的潜力。

3. **文献名称**：*Structural Basis of CDR2 Antibody-Antigen Recognition*

**作者**：Smith GP, et al.

**摘要**：通过X射线晶体学解析了抗CDR2抗体与CDR2抗原表位的结合模式，揭示了抗体互补决定区(CDR)的关键氨基酸残基在抗原识别中的作用。

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**注**：以上为模拟示例，实际文献需通过PubMed、Google Scholar等平台检索关键词(如"CDR2 antibody"、"anti-CDR2")。

背景信息

CDR2 (Complementarity-Determining Region 2) antibodies target the second hypervariable loop within the variable domains of antibody heavy (VH) or light (VL) chains. These regions, along with CDR1 and CDR3. form the antigen-binding site critical for antibody specificity. CDR2 contributes to both structural stability and antigen interaction, though its role is generally less dominant than CDR3 in direct antigen recognition. Research on CDR2 antibodies often focuses on their functional roles in autoimmune diseases, cancer, and infectious diseases. For example, in autoimmune conditions like rheumatoid arthritis or lupus, aberrant CDR2-targeting antibodies may drive pathology by cross-reacting with self-antigens. In cancer immunotherapy, engineered antibodies or T-cell receptors (e.g., CAR-T) sometimes incorporate CDR2 sequences to enhance antigen targeting. Additionally, CDR2-specific monoclonal antibodies are developed as therapeutic agents or diagnostic tools to block pathogenic antibodies or detect disease biomarkers. Challenges include minimizing off-target effects due to CDR2's structural conservation across antibodies and optimizing binding affinity. Recent advances in structural biology and phage display libraries have improved the design of CDR2-directed antibodies, offering potential for more precise therapies. Understanding CDR2's role also aids in studying B-cell receptor signaling and antibody maturation processes.

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