关键信息
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基因名
GLRA1
- 应用
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别名
(Glycine receptor 48 kDa subunit)(Glycine receptor strychnine-binding subunit)
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种属
Human
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表达系统
E. coli
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标签
N- His & C- Myc
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P23415
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表达区间
29-250aa
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分子量
33.1 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
GLRA1 (Glycine Receptor Alpha 1) is a crucial component of the glycine receptor, a ligand-gated ion channel that primarily mediates inhibitory neurotransmission in the central nervous system. Understanding GLRA1 is essential, as mutations in this gene have been linked to various neurological disorders, including hyperekplexia, a condition characterized by exaggerated startle responses. The importance of studying GLRA1 recombinant proteins stems from their potential applications in both basic research and therapeutic development. By producing these proteins in a recombinant system, researchers can investigate their structural and functional properties, elucidate the mechanisms of glycine receptor signaling, and explore how specific mutations affect receptor function. Furthermore, recombinant GLRA1 proteins serve as valuable tools for drug discovery, assisting in the identification of compounds that can modulate receptor activity, which may lead to novel treatments for disorders involving dysregulated glycinergic signaling. Given the diverse roles of glycine receptors in synaptic transmission and their involvement in various neurophysiological processes, understanding GLRA1 through recombinant protein studies provides critical insights into the molecular basis of related diseases and the development of targeted therapies.
