| 纯度 | >95%SDS-PAGE. |
| 种属 | Human |
| 靶点 | TXLNA |
| Uniprot No | P40222 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-162aa |
| 氨基酸序列 | MGSSHHHHHHSSGLVPRGSHMKNQDKKNGAAKQSNPKSSPGQPEAGPEGA QERPSQAAPAVEAEGPGSSQAPRKPEGAQARTAQSGALRDVSEELSRQLE DILSTYCVDNNQGGPGEDGAQGEPAEPEDAEKSRTYVARNGEPEPTPVVN GEKEPSKGDPNTEEIRQSDEVGDRDHRRPQEKLEHHHHHH |
| 预测分子量 | 20 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于TXLNA重组蛋白的3篇示例参考文献(注：以下内容为模拟示例，实际文献需根据具体研究查询)：
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1. **文献名称**：*Expression and Purification of Recombinant TXLNA Protein in Escherichia coli*
**作者**：Zhang, L. et al.
**摘要**：本研究成功构建了TXLNA基因的原核表达载体，并利用大肠杆菌系统高效表达可溶性TXLNA重组蛋白。通过亲和层析和分子筛纯化，获得了高纯度蛋白，并验证其通过Western blot的特异性，为后续功能研究奠定基础。
2. **文献名称**：*Functional Analysis of TXLNA Recombinant Protein in Cancer Cell Apoptosis*
**作者**：Wang, Y. et al.
**摘要**：文章探讨了TXLNA重组蛋白对肿瘤细胞凋亡的调控作用。体外实验表明，该蛋白能显著抑制肝癌细胞增殖并诱导凋亡，其机制可能与激活p53信号通路相关，提示其在癌症治疗中的潜在应用价值。
3. **文献名称**：*Structural Characterization and Immunomodulatory Activity of TXLNA Recombinant Protein*
**作者**：Chen, H. et al.
**摘要**：通过圆二色谱和X射线晶体学解析了TXLNA重组蛋白的三维结构，并发现其能显著增强巨噬细胞的吞噬活性及促炎因子分泌，表明其在免疫调节和感染性疾病中的潜在作用。
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如需查找真实文献，建议在PubMed、CNKI等数据库使用关键词“TXLNA recombinant protein”或“TXLNA 重组蛋白”进行检索。
**Background of TXLNA (Taxilin Alpha) Recombinant Protein**
TXLNA (Taxilin Alpha), encoded by the *TXLNA* gene, is a member of the taxilin family, which includes taxilin-α, -β, and -γ. It is a cytosolic protein implicated in intracellular trafficking, cytoskeletal organization, and cell cycle regulation. Taxilin-α interacts with syntaxins, key components of the SNARE complex, to modulate vesicle transport and membrane fusion processes. Studies suggest its role in regulating autophagy by interacting with mTORC1. a nutrient-sensing kinase complex, thereby influencing cell growth and stress responses.
Recombinant TXLNA protein is produced using expression systems like *E. coli* or mammalian cells, often tagged with histidine or GST for purification. Its production enables functional studies, including protein-protein interaction assays (e.g., pull-downs, co-immunoprecipitation), structural analysis, and mechanistic exploration of its roles in cellular processes. TXLNA’s involvement in cancer has garnered attention, as dysregulated expression is observed in tumors such as gastric and breast cancers, correlating with metastasis and poor prognosis. Recombinant TXLNA serves as a tool to investigate its potential as a diagnostic biomarker or therapeutic target.
Additionally, TXLNA’s interplay with autophagy-related pathways highlights its relevance in neurodegenerative diseases and metabolic disorders. Researchers utilize the recombinant protein to dissect its regulatory mechanisms in health and disease, offering insights into novel treatment strategies. By enabling precise biochemical and cellular analyses, TXLNA recombinant protein remains pivotal in advancing our understanding of intracellular trafficking, cell proliferation, and disease pathogenesis.
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