关键信息
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基因名
TOR2A
- 应用
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别名
TOR2A；TORP1；Torsin-2A
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q5JU69
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表达区间
27-321aa
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氨基酸序列
AWDL ASLRCTLGAF CECDFRPDLP GLECDLAQHL AGQHLAKALV VKALKAFVRD PAPTKPLVLS LHGWTGTGKS YVSSLLAHYL FQGGLRSPRV HHFSPVLHFP HPSHIERYKK DLKSWVQGNL TACGRSLFLF DEMDKMPPGL MEVLRPFLGS SWVVYGTNYR KAIFIFISNT GGKQINQVAL EAWRSRRDRE EILLQELEPV ISRAVLDNPH HGFSNSGIME ERLLDAVVPF LPLQRHHVRH CVLNELAQLG LEPRDEVVQA VLDSTTFFPE DEQLFSSNGC KTVASRIAFF L
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
TOR2A, or Target of Rapamycin 2A, is an essential protein involved in the mTOR signaling pathway, which regulates cell growth, proliferation, and metabolism in response to nutrient availability and stress signals. This pathway plays a critical role in various biological processes, including cellular aging, autophagy, and the development of various diseases such as cancer, obesity, and neurodegenerative disorders. The reconstitution and study of TOR2A recombinant proteins have garnered significant attention in recent years, as they provide valuable insights into the mechanisms regulating cellular homeostasis and metabolic control. Specifically, understanding the structural and functional properties of TOR2A can aid in developing therapeutic strategies aimed at modulating mTOR signaling. Moreover, recombinant TOR2A proteins are instrumental in biochemical assays to investigate their interactions with other molecular partners and to explore their roles in cellular signaling networks. As research continues to unveil the complexities surrounding TOR2A and its implications in health and disease, recombinant TOR2A proteins remain crucial for advancing our understanding of this pivotal signaling pathway and its potential as a therapeutic target.
