关键信息
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基因名
ENA-78/CXCL5
- 应用
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别名
CXCL5; SCYB5; Chemokine C-X-C-Motif Ligand 5; Small Inducible Cytokine Subfamily B(Cys-X-Cys),Member 5; Neutrophil-activating peptide ENA-78
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种属
Human
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 95% as determined by SDS-PAGE.
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蛋白编号
P42830
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表达区间
Arg45~Asn114
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蛋白长度
Partial
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分子量
12kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
ENA-78, also known as CXCL5, is a member of the CXC chemokine family and plays a pivotal role in the immune response, particularly in neutrophil recruitment and activation. It is primarily produced by various cell types, including epithelial cells, and is implicated in several inflammatory processes and diseases, such as chronic obstructive pulmonary disease (COPD), rheumatoid arthritis, and certain cancers. The understanding of ENA-78/CXCL5's role in these conditions underscores its potential as a biomarker and therapeutic target. Recent advancements in recombinant protein technology have enabled the production of ENA-78/CXCL5 in sufficient quantities for detailed biochemical and functional studies. Researchers are investigating the protein's structure-function relationship, signaling pathways, and interactions with its receptor (CXCR2), which are crucial for deciphering its role in health and disease. In addition, studies are exploring how manipulating ENA-78/CXCL5 levels can influence immune responses and inflammation, providing insights for developing new treatments. As a result, generating a recombinant form of ENA-78/CXCL5 is essential for both basic research and potential therapeutic applications, contributing to our understanding of its biological significance and therapeutic utilities in various pathological contexts.
