关键信息
-
基因名
PPARGC1B
- 应用
-
别名
(PGC-1-beta)(PPAR-gamma coactivator 1-beta)(PPARGC-1-beta)(PGC-1-related estrogen receptor alpha coactivator)
-
种属
Human
-
表达系统
E. coli
-
标签
N- His & C- Myc
-
纯度
Greater than 90% as determined by SDS-PAGE.
-
蛋白编号
Q86YN6
-
表达区间
868-1023aa
-
分子量
25.6 kDa
-
内毒素
< 1.0 EU per μg protein as determined by the LAL method.
-
性状
Freeze-dried powder
-
缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
-
稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
PPARGC1B, also known as PGC-1β, is a transcriptional coactivator that plays a crucial role in regulating energy metabolism, mitochondrial biogenesis, and adaptive thermogenesis. It is part of the PGC-1 family, which also includes PGC-1α, both of which are key mediators in the signaling pathways activated by exercise, oxidative stress, and nutritional status. Research has shown that PPARGC1B is involved in various physiological processes, including muscle fiber type switching, insulin sensitivity, and the regulation of genes involved in lipid metabolism. Dysregulation of PPARGC1B has been linked to several metabolic disorders, including obesity, type 2 diabetes, and cardiovascular diseases, making it a significant focus of biomedical research. The study of recombinant PPARGC1B protein is essential for elucidating its functional properties, interactions with other proteins, and downstream effects on gene expression. Utilizing recombinant protein technology allows researchers to investigate the mechanistic roles of PPARGC1B in cellular models and in vivo systems. This research can provide insights into potential therapeutic targets for metabolic diseases and enhance our understanding of energy regulation in various tissues. Overall, the characterization of recombinant PPARGC1B is a vital step in decoding its comprehensive role in metabolism and developing strategies for tackling metabolic dysregulation.
