| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | SLITRK4 |
| Uniprot No | Q8IW52 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-616aa |
| 氨基酸序列 | MFLWLFLILS ALISSTNADS DISVEICNVC SCVSVENVLY VNCEKVSVYR PNQLKPPWSN FYHLNFQNNF LNILYPNTFL NFSHAVSLHL GNNKLQNIEG GAFLGLSALK QLHLNNNELK ILRADTFLGI ENLEYLQADY NLIKYIERGA FNKLHKLKVL ILNDNLISFL PDNIFRFASL THLDIRGNRI QKLPYIGVLE HIGRVVELQL EDNPWNCSCD LLPLKAWLEN MPYNIYIGEA ICETPSDLYG RLLKETNKQE LCPMGTGSDF DVRILPPSQL ENGYTTPNGH TTQTSLHRLV TKPPKTTNPS KISGIVAGKA LSNRNLSQIV SYQTRVPPLT PCPAPCFCKT HPSDLGLSVN CQEKNIQSMS ELIPKPLNAK KLHVNGNSIK DVDVSDFTDF EGLDLLHLGS NQITVIKGDV FHNLTNLRRL YLNGNQIERL YPEIFSGLHN LQYLYLEYNL IKEISAGTFD SMPNLQLLYL NNNLLKSLPV YIFSGAPLAR LNLRNNKFMY LPVSGVLDQL QSLTQIDLEG NPWDCTCDLV ALKLWVEKLS DGIVVKELKC ETPVQFANIE LKSLKNEILC PKLLNKPSAP FTSPAPAITF TTPLGPIRSP PGGPVP |
| 预测分子量 | 69 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于SLITRK4重组蛋白的虚构参考文献示例(仅供格式参考，实际文献需通过学术数据库检索)：
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1. **文献名称**：Expression and Functional Characterization of Recombinant SLITRK4 in Neuronal Development
**作者**：Smith A, et al.
**摘要**：本研究通过哺乳动物表达系统成功制备了SLITRK4重组蛋白，并验证其促进海马神经元突触形成的功能。实验表明，SLITRK4通过激活Trk受体信号通路调节突触可塑性。
2. **文献名称**：Structural Insights into SLITRK4 Recombinant Protein and Its Role in Autism Spectrum Disorders
**作者**：Lee J, et al.
**摘要**：通过重组SLITRK4蛋白的晶体结构解析，揭示了其胞外域与配体结合的关键区域。功能实验表明，SLITRK4异常表达可能通过影响突触蛋白相互作用参与自闭症发病机制。
3. **文献名称**：SLITRK4 Recombinant Protein Attenuates Anxiety-like Behaviors in a Mouse Model
**作者**：Wang X, et al.
**摘要**：利用大肠杆菌表达系统纯化SLITRK4重组蛋白，并在焦虑模型小鼠中验证其治疗潜力。结果显示，SLITRK4通过调节前额叶皮层GABA能信号改善焦虑表型。
4. **文献名称**：Interaction Between Recombinant SLITRK4 and PTPRD: Implications for Synaptic Adhesion
**作者**：Garcia R, et al.
**摘要**：通过体外结合实验证实SLITRK4重组蛋白与酪氨酸磷酸酶PTPRD的直接相互作用，揭示了二者在调控突触黏附及神经元轴突导向中的协同作用。
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**注意**：以上内容为模拟示例，实际文献需查询PubMed、Web of Science等平台。建议使用关键词“SLITRK4 recombinant protein”或“SLITRK4 protein function”进行检索，并筛选近年研究以获取最新进展。
**Background of SLITRK4 Recombinant Protein**
The SLITRK4 (SLIT and NTRK-like family member 4) gene encodes a transmembrane protein belonging to the SLITRK family, which is predominantly expressed in the nervous system. These proteins are characterized by leucine-rich repeat (LRR) domains and a conserved C-terminal region homologous to neurotrophin receptors (Trk). SLITRK members are implicated in neurite outgrowth, synaptic plasticity, and neural circuit formation, with SLITRK4 specifically linked to modulating inhibitory synapses and neurotransmitter release. Dysregulation of SLITRK4 has been associated with neuropsychiatric disorders, including autism spectrum disorders and schizophrenia, as well as certain cancers, highlighting its dual role in neural development and disease.
Recombinant SLITRK4 protein is engineered *in vitro* using expression systems (e.g., mammalian cells or *E. coli*) to produce purified, functional protein for research. Its structure typically includes extracellular LRR domains critical for ligand interaction and intracellular regions involved in signaling. As a tool, recombinant SLITRK4 enables studies on its binding partners, downstream pathways (e.g., MAPK/ERK), and its influence on neuronal connectivity. It also aids in developing disease models, screening therapeutic agents, and generating antibodies. By elucidating SLITRK4's role in health and disease, this recombinant protein serves as a vital resource for advancing neurobiology and precision medicine strategies.
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