| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/100-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | IL14; TXLN |
| WB Predicted band size | 62 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human TXLNA |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是几篇关于BRCA1(Phospho-Ser988)抗体的假设性参考文献示例(仅供参考，实际文献需通过学术数据库验证)：
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1. **文献名称**: *Phosphorylation of BRCA1 at Ser988 regulates DNA damage response*
**作者**: Smith A, et al.
**摘要**: 研究揭示了BRCA1在Ser988位点的磷酸化由ATM激酶介导，参与DNA损伤修复过程。作者通过Phospho-Ser988特异性抗体验证了该修饰在电离辐射后的动态变化及其与RAD51的相互作用。
2. **文献名称**: *Characterization of a novel phosphorylation site in BRCA1 for cancer biomarker development*
**作者**: Lee J, et al.
**摘要**: 开发并验证了一种高特异性BRCA1(Phospho-Ser988)抗体，用于检测乳腺癌组织中的磷酸化水平。研究发现该位点的磷酸化缺失与PARP抑制剂耐药性相关。
3. **文献名称**: *BRCA1 Ser988 phosphorylation modulates its ubiquitin ligase activity*
**作者**: Garcia-Rivera E, et al.
**摘要**: 利用Phospho-Ser988抗体证明该位点磷酸化通过影响BRCA1/BARD1复合物的构象，调控其E3泛素连接酶活性，进而影响DNA修复与细胞周期进程。
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**注意**：以上为假设性示例，实际文献需通过PubMed、Google Scholar等平台搜索关键词“BRCA1 Phospho-Ser988 antibody”或“BRCA1 Ser988 phosphorylation”进行确认。推荐结合具体研究目标筛选相关文献。
The BRCA1 (Phospho-Ser988) antibody is a specialized tool used to detect the phosphorylated form of the BRCA1 protein at serine residue 988. BRCA1. a tumor suppressor protein encoded by the BRCA1 gene, plays critical roles in DNA repair, genomic stability, and cell cycle regulation. Phosphorylation at specific residues, including Ser988. modulates BRCA1's activity in response to DNA damage or cellular stress. This post-translational modification is thought to influence BRCA1's interactions with other repair proteins, such as BARD1. or its recruitment to sites of DNA damage.
The Ser988 phosphorylation site lies within exon 11-encoded regions of BRCA1. an area crucial for multiple protein-protein interactions. While the exact functional significance of Ser988 phosphorylation remains under investigation, it has been associated with BRCA1's role in homologous recombination repair and cell cycle checkpoint control. Researchers utilize this antibody primarily in Western blotting, immunofluorescence, or immunohistochemistry to study phosphorylation dynamics in cancer models, particularly breast and ovarian cancers where BRCA1 dysfunction is prevalent. Its application helps elucidate how post-translational modifications regulate BRCA1's tumor suppressor functions and may contribute to therapeutic resistance mechanisms. Validation typically includes testing in cell lines with known phosphorylation status or DNA damage induction. Specificity is crucial due to potential cross-reactivity with other phosphorylated residues in this structurally complex protein.
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