Cat: PA1000-1782

Recombinant Human LCN2 Protein,His

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关键信息

  • 基因名

    LCN2

  • 应用

    SPRMSTBLIITCELISA细胞实验药物筛选

  • 别名

    LCN2;HNL;NGAL;Neutrophil gelatinase-associated lipocalin

  • 种属

    Human

  • 表达系统

    E. coli

  • 标签

    His tag N-Terminus

  • 纯度

    Greater than 90% as determined by SDS-PAGE.

  • 蛋白编号

    P80188

  • 表达区间

    21-198aa

  • 氨基酸序列

    QDSTSDLIPA PPLSKVPLQQ NFQDNQFQGK WYVVGLAGNA ILREDKDPQK MYATIYELKE DKSYNVTSVL FRKKKCDYWI RTFVPGCQPG EFTLGNIKSY PGLTSYLVRV VSTNYNQHAM VFFKKVSQNR EYFKITLYGR TKELTSELKE NFIRFSKSLG LPENHIVFPV PIDQCIDG

  • 分子量

    20.5 kDa

  • 内毒素

    < 1.0 EU per μg protein as determined by the LAL method.

  • 性状

    Freeze-dried powder

  • 缓冲液

    PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.

  • 复溶方法

    Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.

  • 个性化定制

    点位突变 标签定制 buffer定制 全长蛋白定制

  • 稳定性测试

    The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.

  • 保存条件 & 期限

    Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

  • 运输条件

    In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.

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背景信息

LCN2 (Lipocalin-2) is a multifaceted protein involved in various physiological and pathological processes, including immune response, neuroprotection, and cancer progression. It is part of the lipocalin family, characterized by its ability to bind small hydrophobic molecules, such as fatty acids and hormones, which suggests a role in lipid transport and metabolism. Elevated levels of LCN2 have been associated with numerous conditions, including obesity, diabetes, and inflammatory diseases, indicating its potential as a biomarker for these disorders. In cancer research, LCN2 has been implicated in tumor progression and metastasis, often linked to promoting an inflammatory tumor microenvironment. Given its significant roles in these processes, the study of recombinant LCN2 protein has gained traction to elucidate its function further and explore its therapeutic potential. By employing recombinant DNA technology, researchers can produce LCN2 in substantial quantities, facilitating in vitro and in vivo studies. This allows for a better understanding of its interactions with receptors, downstream signaling pathways, and its role in various cellular contexts. Moreover, investigating LCN2's structure-function relationship could reveal novel mechanisms of action, paving the way for the development of targeted therapies in diseases where LCN2 is dysregulated. Overall, the study of LCN2 not only deepens our knowledge of its biological functions but also opens avenues for novel therapeutic interventions in metabolic and oncological diseases.

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