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Rabbit Polyclonal TUBGCP6 Antibody

  • 中文名: TUBGCP6抗体
  • 别    名: gamma-tubulin complex component 6; GCP-6; GCP6; KIAA1669;
货号: IPDX42415
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/50-1/100 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

Aliasesgamma-tubulin complex component 6; GCP-6; GCP6; KIAA1669;
Entrez GeneID85378;
WB Predicted band size200kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenSynthesized peptide derived from internal of human TUBGCP6.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是3篇关于TUBGCP6抗体的参考文献及其摘要概括(基于公开文献模拟,非真实引用):

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1. **文献名称**: "Characterization of γ-tubulin complex proteins in mitotic spindle assembly"

**作者**: Luders J. et al.

**摘要**: 本研究通过TUBGCP6特异性抗体,揭示了其在哺乳动物细胞有丝分裂中调控微管成核的关键作用。抗体通过免疫荧光证实TUBGCP6定位于中心体,并发现其缺失导致纺锤体异常。

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2. **文献名称**: "TUBGCP6 interacts with centriolar satellites and regulates ciliogenesis"

**作者**: Firat-Karalar E.N. & Stearns T.

**摘要**: 利用TUBGCP6抗体进行免疫共沉淀和Western blot,发现其与中心粒卫星蛋白互作,并证明该蛋白在纤毛形成中的新功能,抗体特异性验证通过siRNA敲低实验确认。

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3. **文献名称**: "Dysregulation of γ-tubulin network in cancer: Role of TUBGCP6 overexpression"

**作者**: Wang Y. et al.

**摘要**: 通过TUBGCP6抗体分析临床样本,发现其在多种癌症中高表达,并促进肿瘤细胞增殖。研究采用免疫组化及流式细胞术,证实抗体在区分正常与癌变组织中的诊断潜力。

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如需具体文献,建议在PubMed或Web of Science中搜索最新研究,并关注抗体应用相关的功能研究(如定位、互作或疾病机制)。

背景信息

The TUBGCP6 antibody targets the Tubulin Gamma Complex Component 6 (TUBGCP6), a critical protein within the gamma-tubulin ring complex (γ-TuRC). This multi-subunit complex serves as a structural template for microtubule nucleation, essential for mitotic spindle formation, chromosome segregation, and maintaining cytoskeletal organization. TUBGCP6. along with other γ-TuRC components, anchors γ-tubulin to cellular structures like centrosomes, ensuring proper microtubule assembly and mitotic fidelity. Antibodies against TUBGCP6 are widely used to study its localization, expression, and functional roles in cell division, particularly in cancer research where dysregulated microtubule dynamics contribute to genomic instability. They are also employed in exploring developmental disorders linked to γ-TuRC mutations. Common applications include immunofluorescence, Western blotting, and co-immunoprecipitation to dissect protein interactions. Validation often involves knockout or knockdown models to confirm specificity. Research using TUBGCP6 antibodies has advanced understanding of microtubule-related pathologies and potential therapeutic targets, highlighting its importance in both basic and translational cell biology.

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