| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | golgi phosphoprotein 6; golgi reassembly-stacking protein 2; GOLPH6; GORS2; GRASP55 |
| Entrez GeneID | 26003; |
| WB Predicted band size | 47kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Synthesized peptide derived from internal of human GORASP2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇关于GORASP2抗体的文献概述(基于公开研究数据模拟，非真实文献)：
1. **文献名称**：GORASP2 as a novel regulator of Golgi structure and cancer cell invasion
**作者**：Smith J, et al.
**摘要**：本研究利用GORASP2特异性抗体，发现其在维持高尔基体形态中的作用，并证明其过表达促进肿瘤细胞迁移和侵袭，提示其作为癌症治疗靶点的潜力。
2. **文献名称**：Antibody-based profiling of GORASP2 reveals isoform-specific interactions in neuronal cells
**作者**：Lee S, et al.
**摘要**：通过开发GORASP2亚型特异性抗体，揭示了该蛋白在神经元高尔基体分选过程中的选择性相互作用，并发现其与阿尔茨海默病模型中β-淀粉样蛋白异常分泌相关。
3. **文献名称**：GORASP2 knockdown impairs collagen secretion through antibody-validated Golgi trafficking disruption
**作者**：Zhang R, et al.
**摘要**：使用GORASP2抗体验证其敲低导致胶原蛋白分泌障碍，证实其在细胞外基质形成中的关键作用，为纤维化疾病机制提供新见解。
注：以上内容为基于领域知识的模拟文献，实际引用请通过PubMed/Google Scholar检索真实文献(关键词：GORASP2 antibody, GRASP2 Golgi function)。
GORASP2 (Golgi Reassembly and Stacking Protein 2), also known as GRASP55. is a ubiquitously expressed peripheral membrane protein critical for Golgi apparatus structure and function. It belongs to the GRASP family, which includes GRASP65 (GORASP1) and GRASP55. These proteins facilitate Golgi stacking and reassembly during mitosis, ensuring proper vesicle trafficking, glycosylation, and protein sorting. GORASP2 localizes predominantly to the medial- and trans-Golgi cisternae, where it interacts with golgins and other scaffolding proteins to maintain Golgi integrity. Beyond its structural role, GORASP2 participates in unconventional protein secretion, autophagy, and cellular stress responses, linking Golgi dynamics to broader cellular processes.
Antibodies targeting GORASP2 are widely used to study Golgi organization, vesicular transport mechanisms, and disease-related Golgi dysfunction. They are essential tools in techniques like immunofluorescence, Western blotting, and immunohistochemistry to visualize GORASP2 expression, localization, and post-translational modifications (e.g., phosphorylation during mitosis). Dysregulation of GORASP2 has been implicated in cancers, neurodegenerative diseases (e.g., Alzheimer’s), and infectious diseases, as pathogens often exploit Golgi pathways. Commercial GORASP2 antibodies are typically raised in rabbits or mice, validated for specificity across human, mouse, and rat models. Researchers must verify antibody performance in specific experimental contexts, as isoforms or phosphorylation states may affect detection.
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