Rabbit Polyclonal GIDRP88 Antibody

The GIDRP88 antibody is a research tool designed to target the GID complex subunit RP88. a protein implicated in cellular regulatory processes such as protein degradation and cell cycle control. The GID complex, conserved across eukaryotes, functions as an E3 ubiquitin ligase, marking specific substrates for proteasomal degradation via ubiquitination. GIDRP88 (also known as GID8 or CCDC92) plays a critical role in this complex, particularly in mediating substrate recognition and complex stability. Studies suggest its involvement in metabolic regulation, DNA damage response, and cell proliferation, with dysregulation linked to cancers and neurodegenerative diseases. The GIDRP88 antibody is typically generated in model organisms (e.g., rabbits or mice) using recombinant protein fragments or synthetic peptides as immunogens. It is validated for applications like Western blotting, immunofluorescence, and immunoprecipitation to study GIDRP88 expression, localization, and interaction networks. Commercial versions are available from multiple biotech suppliers, often accompanied by validation data in specific experimental conditions. Researchers utilize this antibody to explore GIDRP88's role in ubiquitin-proteasome pathways, its association with disease mechanisms, and potential therapeutic targets. However, batch variability and cross-reactivity remain challenges, requiring careful experimental optimization.