| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | homeo box 1C; homeo box A5; homeobox A5; Homeobox protein Hox-1C; Homeobox protein Hox-A5 |
| Entrez GeneID | 3202; |
| WB Predicted band size | 30kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Synthesized peptide derived from N-terminal of human HXA5. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇关于HOXA5抗体的模拟参考文献示例(注：HXA5可能为HOXA5的笔误，以下按HOXA5相关研究整理，若需HXA5特异抗体文献请核实基因名称)：
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1. **文献名称**：HOXA5 Antibody-Based Immunohistochemical Analysis in Breast Cancer Prognosis
**作者**：Li Y, et al.
**摘要**：本研究开发了一种高特异性HOXA5单克隆抗体，用于检测乳腺癌组织中HOXA5蛋白表达。通过对452例患者的组织样本分析，发现HOXA5低表达与肿瘤转移风险增加及患者总生存期缩短显著相关，提示其作为预后生物标志物的潜力。
2. **文献名称**：HOXA5 Epigenetic Silencing and Antibody Validation in Lung Adenocarcinoma
**作者**：Martinez R, et al.
**摘要**：通过甲基化测序发现HOXA5启动子在肺癌中频繁甲基化，导致表达抑制。利用兔源多克隆HOXA5抗体进行Western blot和免疫组化验证，证实抗体特异性，并发现HOXA5表达缺失与EGFR突变存在协同效应。
3. **文献名称**：HOXA5 as a Therapeutic Target in Colorectal Cancer: Antibody Development and Functional Studies
**作者**：Chen X, Wang H
**摘要**：研究团队通过噬菌体展示技术筛选出人源化HOXA5抗体(mAb-H5)，体外实验显示该抗体可阻断HOXA5与Wnt/β-catenin通路相互作用，抑制结肠癌细胞增殖并增强化疗敏感性，为靶向治疗提供新策略。
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**备注**：
- 若需真实文献，建议在PubMed中检索关键词“HOXA5 antibody”或“HOXA5 immunohistochemistry”，重点关注近5年肿瘤学领域研究。
- 如确需HXA5(非HOXA5)相关研究，可能需核实基因命名或检查拼写误差。
The HXA5 antibody targets the HXA5 protein, a member of the homeobox (HOX) gene family, which plays critical roles in embryonic development, cellular differentiation, and tissue patterning. HOX genes encode transcription factors containing a conserved DNA-binding domain (homeodomain) that regulates gene expression by binding to specific sequences. HXA5 (Homeobox A5) is particularly implicated in organogenesis, including lung, gut, and mammary gland development, and is involved in maintaining cellular identity and function. Dysregulation of HXA5 has been linked to pathological conditions, such as cancer, where its reduced expression correlates with tumor progression, metastasis, and poor prognosis in cancers like breast, lung, and colorectal malignancies.
HXA5 antibodies are essential tools for detecting and quantifying HXA5 protein levels in research. They are widely used in techniques like immunohistochemistry (IHC), Western blotting, and immunofluorescence to study HXA5's spatial and temporal expression patterns in tissues or cultured cells. These antibodies also facilitate investigations into HXA5's molecular interactions, regulatory pathways, and epigenetic modifications (e.g., promoter methylation) that silence its expression in diseases. Recent studies explore HXA5's potential as a biomarker for cancer diagnosis or therapeutic targeting. However, antibody specificity remains a challenge due to structural similarities among HOX family proteins, necessitating rigorous validation in experimental models.
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