| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | CT15; FTNB; PH30; CRYN1; CRYN2; PH-30b |
| Entrez GeneID | 2515; |
| WB Predicted band size | 64kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein corresponding to residues near the C terminal of human ADAM metallopeptidase domain 2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于ADAM2抗体的参考文献示例(请注意，以下内容为假设性示例，实际文献需通过学术数据库验证)：
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1. **文献名称**: *"Characterization of ADAM2 in Sperm-Egg Fusion Using Monoclonal Antibodies"*
**作者**: Smith A, et al.
**摘要**: 本研究开发并验证了一种针对ADAM2的单克隆抗体，证实其在哺乳动物精子表面的特异性表达。通过免疫荧光和蛋白质印迹分析，揭示了ADAM2在精子-卵子膜融合中的关键作用。
2. **文献名称**: *"ADAM2 Expression in Infertility: Immunohistochemical Analysis with a Novel Polyclonal Antibody"*
**作者**: Lee B, et al.
**摘要**: 作者报道了一种新型多克隆抗体的开发，用于检测人类睾丸组织中的ADAM2蛋白。研究发现ADAM2表达缺失与男性不育症相关，为临床诊断提供了潜在标志物。
3. **文献名称**: *"Role of ADAM2 in Sperm Motility: Insights from Antibody-Mediated Functional Blockade"*
**作者**: Garcia C, et al.
**摘要**: 利用ADAM2特异性抗体阻断实验，本研究揭示了ADAM2在小鼠精子运动能力和穿透卵子透明带中的调控机制，强调了其作为治疗靶点的潜力。
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**备注**：上述文献为示例，实际引用时请通过PubMed、Google Scholar等平台检索最新研究，并核实内容准确性。ADAM2相关研究多集中于生殖生物学领域，建议结合关键词“ADAM2 antibody”和“sperm”或“infertility”进行深入检索。
ADAM2 (A Disintegrin And Metalloprotease 2), also known as PH-30. is a member of the ADAM family of transmembrane glycoproteins. These proteins are characterized by a conserved domain structure, including a prodomain, metalloprotease domain, disintegrin-like domain, cysteine-rich region, transmembrane domain, and cytoplasmic tail. ADAM2 is primarily studied in the context of reproductive biology, where it plays a critical role in sperm-egg interactions during fertilization. It is a key component of the sperm surface protein complex (e.g., with ADAM3) involved in zona pellucida binding and membrane fusion.
Research on ADAM2 antibodies has focused on elucidating its functional mechanisms in fertility and its potential association with male infertility. Antibodies targeting ADAM2 are utilized in techniques like Western blotting, immunohistochemistry, and immunofluorescence to study its expression patterns in testes, spermatozoa, and other tissues. Some studies also explore its limited expression in somatic cells and possible roles in cancer or immunological processes. Commercial ADAM2 antibodies are typically validated for specificity against recombinant protein fragments or epitopes within its disintegrin or cysteine-rich domains. However, challenges persist due to homology among ADAM family members, requiring careful antibody validation. Its clinical relevance remains an active area of investigation, particularly in diagnosing or treating fertility disorders.
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