Rabbit Polyclonal AHI1 Antibody

The AHI1 (Abelson helper integration site 1) gene encodes a protein involved in neuronal development and cellular signaling. AHI1 antibodies are tools used to detect and study the AHI1 protein, which contains multiple functional domains, including WD40 repeats and an SH3 domain, suggesting roles in protein-protein interactions and intracellular signaling. AHI1 is critical for cerebellar and retinal development; mutations in this gene are linked to Joubert syndrome, a rare neurodevelopmental disorder characterized by brainstem malformations, hypotonia, and developmental delays. Research using AHI1 antibodies has elucidated its localization in cilia and centrosomes, highlighting its importance in ciliogenesis and neuronal migration. Additionally, AHI1 dysregulation has been implicated in cancers and psychiatric disorders, though mechanisms remain under investigation. These antibodies are essential for techniques like Western blotting, immunohistochemistry, and immunofluorescence, enabling researchers to explore AHI1's expression patterns, interactions, and pathological contributions. Understanding AHI1's functions through antibody-based studies provides insights into developmental disorders and potential therapeutic targets.