| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | EA6; EAAT1; GLAST1; Slc1a3;;EAAT1 |
| WB Predicted band size | Calculated MW: 60 kDa ; Observed MW: 59 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human EAAT1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是3篇与LPP抗体相关的参考文献(内容基于公开摘要概括，非真实文献，仅供格式参考)：
1. **文献名称**: "Characterization of LPP Protein Expression in Human Cancers Using a Novel Monoclonal Antibody"
**作者**: Müller S. et al.
**摘要**: 本研究开发了一种新型抗LPP单克隆抗体，用于检测多种癌症组织中LPP蛋白的表达水平。结果显示，LPP在转移性肿瘤中高表达，提示其可能作为癌症侵袭性的潜在生物标志物。
2. **文献名称**: "LPP Antibody-Based Detection of Focal Adhesion Dynamics in Cell Migration"
**作者**: Kim J.H., Park T.
**摘要**: 通过LPP特异性抗体研究细胞黏着斑动态变化，发现LPP蛋白通过调控细胞骨架重组参与肿瘤细胞迁移过程，为靶向LPP的抗转移治疗提供理论依据。
3. **文献名称**: "Autoantibodies Against LPP Protein in Autoimmune Diseases: A Cross-Sectional Study"
**作者**: Rodriguez E. et al.
**摘要**: 首次报道系统性红斑狼疮(SLE)患者血清中存在抗LPP自身抗体，提示LPP可能参与自身免疫反应的分子机制，或成为SLE的新型血清学诊断指标。
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如需真实文献，建议通过PubMed或Google Scholar检索关键词 "LPP antibody" 或 "LIM domain-containing protein antibody"，并筛选近5年高被引论文。部分研究可能涉及LPP在细胞粘附、癌症转移或免疫疾病中的作用。
Leukemia-associated fusion proteins, particularly those involving the LPP (LIM domain containing preferred translocation partner in lipoma) gene, have been studied extensively in cancer biology. LPP encodes a protein with three LIM domains, which mediate protein-protein interactions and transcriptional regulation. Initially identified in lipomas, LPP gained attention due to its role in chromosomal translocations, notably t(3;12)(q28;q14), which fuses LPP with HMGA2 in benign mesenchymal tumors. However, LPP rearrangements are also implicated in hematologic malignancies, such as acute lymphoblastic leukemia (ALL), where translocations (e.g., t(3;11)(q28;p15)) form oncogenic fusion proteins like LPP-HMGA2 or LPP-TFE3. These fusions disrupt normal transcriptional regulation, promoting cell proliferation and survival.
LPP antibodies are critical tools for detecting LPP fusion proteins and wild-type LPP expression in research and diagnostics. They aid in identifying translocation events via techniques like immunohistochemistry, Western blotting, or fluorescence in situ hybridization (FISH). Beyond cancer, LPP antibodies help study LPP's physiological roles, including its involvement in cell adhesion, migration, and cytoskeletal dynamics. Recent studies also explore LPP's interaction with signaling pathways (e.g., Wnt/β-catenin) in tumorigenesis. Validated LPP antibodies are essential for understanding both pathological mechanisms and potential therapeutic targets in malignancies and connective tissue disorders.
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