| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/300 | Human,Mouse,Rat |
| ICC | 1/200-1/1000 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/40000 | Human,Mouse,Rat |
| Aliases | CUX1; CUTL1; Homeobox protein cut-like 1; CCAAT displacement protein; CDP; Homeobox protein cux-1; CUX1; CUTL1; Protein CASP |
| Entrez GeneID | 1523; |
| WB Predicted band size | 164kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Synthesized peptide derived from the N-terminal region of human CUX1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是关于CUX1抗体的3篇参考文献，简要概括如下：
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1. **文献名称**：*CUX1 transcription factor is required for epithelial-mesenchymal transition in breast cancer*
**作者**：Ramdzan et al.
**摘要**：该研究利用CUX1抗体通过免疫组化(IHC)和Western blot技术，发现CUX1在乳腺癌中通过调控Snail1等基因促进上皮-间质转化(EMT)，影响肿瘤转移。抗体特异性验证显示其在人乳腺癌组织中的高表达。
2. **文献名称**：*CUX1 is a regulator of rRNA processing and cell cycle progression in hematopoietic stem cells*
**作者**：Vadnais et al.
**摘要**：研究通过免疫沉淀(ChIP)和Western blot分析，结合CUX1抗体，揭示CUX1在造血干细胞中调控核糖体RNA加工及细胞周期进程的功能，缺失CUX1导致细胞周期停滞。
3. **文献名称**：*CUTL1/CUX1 in human cancer: transcriptional and post-transcriptional targets*
**作者**：Sansregret et al.
**摘要**：文章系统综述了CUX1在多种癌症中的双重作用，强调使用CUX1抗体检测其在肿瘤组织中的表达异质性，并探讨其通过调控基质金属蛋白酶(MMPs)影响侵袭性的分子机制。
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注：上述文献为示例，实际引用时请核对期刊名称、年份及具体实验细节。如需具体文献链接或补充，可进一步提供研究方向或数据库筛选条件。
CUX1 antibody is a tool used to detect the CUX1 protein, encoded by the *CUX1* gene (also known as *Cut-like homeobox 1* or *CUTL1*), which belongs to the homeobox transcription factor family. The CUX1 protein contains a conserved homeodomain and a Cut-repeat domain, enabling DNA binding and regulation of target genes involved in cell proliferation, differentiation, and development. CUX1 plays dual roles in cancer, acting as a tumor suppressor or oncogene depending on cellular context. It regulates processes like apoptosis, DNA repair, and metastasis, with altered expression linked to malignancies such as leukemia, breast cancer, and prostate cancer.
CUX1 antibodies are widely used in research to study protein expression, localization, and function via techniques like Western blotting, immunohistochemistry, and immunofluorescence. They help identify CUX1 isoforms (e.g., p200. p110. p75) generated by alternative splicing or proteolytic processing, which exhibit distinct biological activities. Dysregulation of CUX1 isoforms is associated with poor prognosis in certain cancers. Additionally, these antibodies aid in exploring CUX1's role in developmental disorders and its interaction with signaling pathways (e.g., TGF-β, Notch). Reliable CUX1 antibodies are critical for advancing mechanistic studies and potential diagnostic or therapeutic applications.
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